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Chemical Compound Review:

AG-K-57845 2,3- dihexadecanoyloxypropoxyphosph onic acid

Synonyms: BSPBio_001456, KBioGR_000176, KBioSS_000176, CBiol_001831, AC1Q6SMV, ...

Lai, C.S. et al., Girke, S. et al., Pemberton, J.E. et al., Wang, H.Y. et al.

Pemberton, Chamberlain,

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High impact information on dipalmitoylphosphatidic acid

Diphtheria toxin (DT) induces the leakage of dipalmitoylphosphatidic acid (DPPA) membranes but not neutral dipalmitoylphosphatidylcholine (DPPC) membranes [1].
The ESR spectrum indicates that PMB also causes interdigitation of DPPA [2].

Anatomical context of dipalmitoylphosphatidic acid

This saturation phenomenon led to the postulation that DT binds to the first shell of DPPA membranes and induces the leakage of TEMPOcholine limited to this layer of DPPA multimellar vesicles [1].

Analytical, diagnostic and therapeutic context of dipalmitoylphosphatidic acid

The perturbing action of the drugs on phospholipid-membranes was evaluated by determining the drug-effect on the temperature of the phase-transition from the gel to the liquid crystalline state in liposomes of dipalmitoylphosphatidic acid by means of differential scanning calorimetry [3].
Raman spectroscopy of model membrane monolayers of dipalmitoylphosphatidic acid at the air-water interface using surface enhancement from buoyant thin silver films [4].

References

Diphtheria toxin induces leakage of acidic liposomes. Lai, C.S., Kushnaryov, V., Panz, T., Basosi, R. Arch. Biochem. Biophys. (1984) [Pubmed]
Use of spin labels to determine the percentage of interdigitated lipid in complexes with polymyxin B and polymyxin B nonapeptide. Wang, H.Y., Tümmler, B., Boggs, J.M. Biochim. Biophys. Acta (1989) [Pubmed]
Comparison between the activities of cationic amphiphilic drugs to affect phospholipid-membranes and to depress cardiac function. Girke, S., Mohr, K., Schrape, S. Biochem. Pharmacol. (1989) [Pubmed]
Raman spectroscopy of model membrane monolayers of dipalmitoylphosphatidic acid at the air-water interface using surface enhancement from buoyant thin silver films. Pemberton, J.E., Chamberlain, J.R. Biopolymers (2000) [Pubmed]

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