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Chemical Compound Review:

MU-Ac (4-methyl-2-oxo-chromen-7-yl) ethanoate

Synonyms: PubChem8663, CPD-181, CHEMBL12019, NSC-1059, AG-A-76679, ...

Garcia-Sastre, A. et al., Berman, H.A. et al., Pindel, E.V. et al., Dean, R.A. et al., Lee, W.H. et al.

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High impact information on C03837

The Km of esterase D was estimated to be 10 X 10(-6) M using 4-methylumbelliferyl acetate as substrate [1].
A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine was purified from human liver [2].
The use of 4-nitrophenyl acetate, 4-methylumbelliferyl acetate or 1-naphthyl acetate as substrate seems to be convenient for routine work, but it is better to carry out the measurements in parallel with those on bovine submandibular gland mucin (the latter is a natural and commercially available substrate) [3].
While all cations cause linear mixed inhibition of acetylthiocholine hydrolysis, there are observed a variety of inhibition patterns of 7AMC and p-nitrophenyl acetate hydrolysis that are distinctly nonlinear, as well as patterns in which the reciprocal plots intersect in the upper right quadrant [4].
The tissue distribution of three nonspecific esterases, A, B and C, was defined by nondenaturing gel electrophoresis and measuring the hydrolysis of 4-methylumbelliferyl acetate in the gels [5].

References

Purification, biochemical characterization, and biological function of human esterase D. Lee, W.H., Wheatley, W., Benedict, W.F., Huang, C.M., Lee, E.Y. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. Pindel, E.V., Kedishvili, N.Y., Abraham, T.L., Brzezinski, M.R., Zhang, J., Dean, R.A., Bosron, W.F. J. Biol. Chem. (1997) [Pubmed]
Activity of influenza C virus O-acetylesterase with O-acetyl-containing compounds. Garcia-Sastre, A., Villar, E., Manuguerra, J.C., Hannoun, C., Cabezas, J.A. Biochem. J. (1991) [Pubmed]
Ligand exclusion on acetylcholinesterase. Berman, H.A., Leonard, K. Biochemistry (1990) [Pubmed]
Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein. Dean, R.A., Zhang, J., Brzezinski, M.R., Bosron, W.F. J. Pharmacol. Exp. Ther. (1995) [Pubmed]

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