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Chemical Compound Review:

Pcb-95 1,2,4-trichloro-3-(2,5- dichlorophenyl)benzene

Synonyms: Pcb 95, AG-F-35335, SureCN4450570, CTK4H9861, LS-182472, ...

Gafni, J. et al., Rogers, J.M. et al., Schantz, S.L. et al., Bemis, J.C. et al., Wong, P.W. et al.

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Psychiatry related information on Pcb 95

Long-term effects of developmental exposure to 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding [1].

High impact information on Pcb 95

Exposure of fetuses to the PCB mixture Aroclor 1254 and the non-coplanar congener 2,3,6,2',5'-pentachlorobiphenyl (PCB95) did not result in any activation of the lacZ transgene [2].
The mechanisms by which non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) and rapamycin interact with ryanodine receptor (RyR) complexes to alter Ca2+ signaling, were explored in intact cerebellar granule neurons [3].
Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors [3].
Of the PCBs evaluated, 2,2',3,5',6-pentachlorobiphenyl (PCB 95) exhibits the highest potency and efficacy towards the ryanodine receptor in vitro [1].

Biological context of Pcb 95

Ortho-substituted 2,2',3,5',6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity in vitro: evidence for altered hippocampal function [4].

Analytical, diagnostic and therapeutic context of Pcb 95

The utility of BG1Luc4E(2) cells as a bioassay screening system for environmental estrogens was demonstrated by their response to known xenoestrogens, and also by the putative identification of two polychlorinated biphenyls (2,3',4, 4,'-tetrachlorobiphenyl and 2,2',3,5',6-pentachlorobiphenyl) as novel estrogenic chemicals [5].

References

Long-term effects of developmental exposure to 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding. Schantz, S.L., Seo, B.W., Wong, P.W., Pessah, I.N. Neurotoxicology (1997) [Pubmed]
Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Bemis, J.C., Nazarenko, D.A., Gasiewicz, T.A. Toxicol. Sci. (2005) [Pubmed]
Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Gafni, J., Wong, P.W., Pessah, I.N. Toxicol. Sci. (2004) [Pubmed]
Ortho-substituted 2,2',3,5',6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity in vitro: evidence for altered hippocampal function. Wong, P.W., Joy, R.M., Albertson, T.E., Schantz, S.L., Pessah, I.N. Neurotoxicology (1997) [Pubmed]
Recombinant cell bioassays for endocrine disruptors: development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals. Rogers, J.M., Denison, M.S. In vitro & molecular toxicology. (2000) [Pubmed]

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