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Chemical Compound Review

Aurothiomalate     1,2-dicarboxyethanethiolate; gold(+1) cation

Synonyms: CHEBI:38722, NSC-147828, NSC147828, 33796-26-8, (1,2-dicarboxyethylthio)gold, ...
This record was replaced with 6268.
 
 
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High impact information on Monomercaptosuccinic acid

  • As reported previously, morphological features of apoptosis (pyknosis, cellular condensation) and atresia (granulosa cell disorganization, oocyte pseudomaturation) remained detectable in SAM-treated follicles [1].
  • Incubation of follicles in the presence of a putative irreversible and non-competitive inhibitor of caspase-1 (interleukin-1beta-converting enzyme or ICE), sodium aurothiomalate (SAM), completely prevented internucleosomal, but not high MW, DNA cleavage [1].

References

  1. High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays. Trbovich, A.M., Hughes, F.M., Perez, G.I., Kugu, K., Tilly, K.I., Cidlowski, J.A., Tilly, J.L. Cell Death Differ. (1998) [Pubmed]
 
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