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Gene Review

Casp1  -  caspase 1

Rattus norvegicus

Synonyms: CASP-1, Caspase-1, ICE, IL-1 beta-converting enzyme, IL-1BC, ...
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Disease relevance of Casp1


Psychiatry related information on Casp1

  • Changes in caspase expression in Alzheimer's disease: comparison with development and aging [6].
  • In a rat excitotoxic model of Huntington's disease in which an excitotoxin is infused into the striatum to activate NMDA receptors, short-term lithium pretreatment is sufficient to protect against DNA damage, caspase activation, and apoptosis of striatal neurons, and this neuroprotection is concurrent with Bcl-2 induction [7].
  • However, only a slight effect of the caspase inhibitor across the session was found. z-DEVD-fmk impaired development of some essential components of the two-way active avoidance performance, such as escape reaction, conditioned fear reaction, and inter-trial crossings [8].
  • These results indicate an opioid-induced neurotoxic consequence regulated by the NMDAR-caspase pathway, a mechanism that may have clinical implications in opioid therapy and substance abuse [9].

High impact information on Casp1


Chemical compound and disease context of Casp1


Biological context of Casp1


Anatomical context of Casp1


Associations of Casp1 with chemical compounds


Physical interactions of Casp1


Enzymatic interactions of Casp1


Regulatory relationships of Casp1


Other interactions of Casp1


Analytical, diagnostic and therapeutic context of Casp1


  1. Exogenous Expression of Fas-Ligand or CrmA Prolongs the Survival in Rat Liver Transplantation. Adachi, K., Fujino, M., Kitazawa, Y., Funeshima-Fuji, N., Takahara, S., Kimura, H., Li, X.K. Transplant. Proc. (2006) [Pubmed]
  2. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. Kasahara, Y., Tuder, R.M., Taraseviciene-Stewart, L., Le Cras, T.D., Abman, S., Hirth, P.K., Waltenberger, J., Voelkel, N.F. J. Clin. Invest. (2000) [Pubmed]
  3. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Bialik, S., Cryns, V.L., Drincic, A., Miyata, S., Wollowick, A.L., Srinivasan, A., Kitsis, R.N. Circ. Res. (1999) [Pubmed]
  4. Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Sawada, M., Nakashima, S., Banno, Y., Yamakawa, H., Hayashi, K., Takenaka, K., Nishimura, Y., Sakai, N., Nozawa, Y. Cell Death Differ. (2000) [Pubmed]
  5. ICE-like protease (caspase) is involved in transforming growth factor beta1-mediated apoptosis in FaO rat hepatoma cell line. Choi, K.S., Lim, I.K., Brady, J.N., Kim, S.J. Hepatology (1998) [Pubmed]
  6. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Shimohama, S., Tanino, H., Fujimoto, S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  7. The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials. Chuang, D.M. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  8. Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Stepanichev, M.Y., Kudryashova, I.V., Yakovlev, A.A., Onufriev, M.V., Khaspekov, L.G., Lyzhin, A.A., Lazareva, N.A., Gulyaeva, N.V. Neuroscience (2005) [Pubmed]
  9. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. Mao, J., Sung, B., Ji, R.R., Lim, G. J. Neurosci. (2002) [Pubmed]
  10. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Schierle, G.S., Hansson, O., Leist, M., Nicotera, P., Widner, H., Brundin, P. Nat. Med. (1999) [Pubmed]
  11. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Springer, J.E., Azbill, R.D., Knapp, P.E. Nat. Med. (1999) [Pubmed]
  12. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Li, P.F., Li, J., Müller, E.C., Otto, A., Dietz, R., von Harsdorf, R. Mol. Cell (2002) [Pubmed]
  13. Protein Kinase C-Dependent Mitochondrial Translocation of Proapoptotic Protein Bax on Activation of Inducible Nitric-Oxide Synthase in Rostral Ventrolateral Medulla Mediates Cardiovascular Depression during Experimental Endotoxemia. Chan, J.Y., Chang, A.Y., Wang, L.L., Ou, C.C., Chan, S.H. Mol. Pharmacol. (2007) [Pubmed]
  14. Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation. Dong, Z., Saikumar, P., Patel, Y., Weinberg, J.M., Venkatachalam, M.A. Biochem. J. (2000) [Pubmed]
  15. Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes. Germack, R., Griffin, M., Dickenson, J.M. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  16. Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Baydas, G., Reiter, R.J., Akbulut, M., Tuzcu, M., Tamer, S. Neuroscience (2005) [Pubmed]
  17. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Du, Y., Bales, K.R., Dodel, R.C., Hamilton-Byrd, E., Horn, J.W., Czilli, D.L., Simmons, L.K., Ni, B., Paul, S.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and {beta}-Cell Lines. Collier, J.J., Fueger, P.T., Hohmeier, H.E., Newgard, C.B. Diabetes (2006) [Pubmed]
  19. Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. Asahi, M., Hoshimaru, M., Uemura, Y., Tokime, T., Kojima, M., Ohtsuka, T., Matsuura, N., Aoki, T., Shibahara, K., Kikuchi, H. J. Cereb. Blood Flow Metab. (1997) [Pubmed]
  20. Caspaselike proteases activated in apoptotic photoreceptors of Royal College of Surgeons rats. Katai, N., Kikuchi, T., Shibuki, H., Kuroiwa, S., Arai, J., Kurokawa, T., Yoshimura, N. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  21. Differential c-Fos and caspase expression following kainic acid excitotoxicity. Ferrer, I., López, E., Blanco, R., Rivera, R., Krupinski, J., Martí, E. Acta Neuropathol. (2000) [Pubmed]
  22. Prevention of bile acid-induced apoptosis by betaine in rat liver. Graf, D., Kurz, A.K., Reinehr, R., Fischer, R., Kircheis, G., Häussinger, D. Hepatology (2002) [Pubmed]
  23. Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with pneumocystis pneumonia. Lasbury, M.E., Durant, P.J., Ray, C.A., Tschang, D., Schwendener, R., Lee, C.H. J. Immunol. (2006) [Pubmed]
  24. B cell apoptosis triggered by antigen receptor ligation proceeds via a novel caspase-dependent pathway. Chen, W., Wang, H.G., Srinivasula, S.M., Alnemri, E.S., Cooper, N.R. J. Immunol. (1999) [Pubmed]
  25. Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb. Lemaire, C., Godefroy, N., Costina-Parvu, I., Rincheval, V., Renaud, F., Trotot, P., Bouleau, S., Mignotte, B., Vayssière, J.L. Oncogene (2005) [Pubmed]
  26. AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9. Chong, Z.Z., Kang, J.Q., Maiese, K. Exp. Cell Res. (2004) [Pubmed]
  27. Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. Stoka, V., Turk, V., Bredesen, D.E. FEBS Lett. (2006) [Pubmed]
  28. Caspase inhibition decreases cell death in regions of adult neurogenesis. Biebl, M., Winner, B., Winkler, J. Neuroreport (2005) [Pubmed]
  29. The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons. Camandola, S., Poli, G., Mattson, M.P. J. Neurochem. (2000) [Pubmed]
  30. Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein. Kim, H.S., Kim, E.M., Kim, N.J., Chang, K.A., Choi, Y., Ahn, K.W., Lee, J.H., Kim, S., Park, C.H., Suh, Y.H. J. Neurosci. Res. (2004) [Pubmed]
  31. Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. Weng, C., Li, Y., Xu, D., Shi, Y., Tang, H. J. Biol. Chem. (2005) [Pubmed]
  32. Definition and redesign of the extended substrate specificity of granzyme B. Harris, J.L., Peterson, E.P., Hudig, D., Thornberry, N.A., Craik, C.S. J. Biol. Chem. (1998) [Pubmed]
  33. Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation. Hurelbrink, C.B., Armstrong, R.J., Luheshi, L.M., Dunnett, S.B., Rosser, A.E., Barker, R.A. Exp. Neurol. (2001) [Pubmed]
  34. Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury. Warren, M.W., Kobeissy, F.H., Liu, M.C., Hayes, R.L., Gold, M.S., Wang, K.K. Life Sci. (2005) [Pubmed]
  35. Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia. Tyagi, N., Ovechkin, A.V., Lominadze, D., Moshal, K.S., Tyagi, S.C. J. Cell. Biochem. (2006) [Pubmed]
  36. Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways. Fu, Y.C., Chi, C.S., Yin, S.C., Hwang, B., Chiu, Y.T., Hsu, S.L. Cardiovasc. Res. (2004) [Pubmed]
  37. p53 can promote mitochondria- and caspase-independent apoptosis. Godefroy, N., Lemaire, C., Renaud, F., Rincheval, V., Perez, S., Parvu-Ferecatu, I., Mignotte, B., Vayssière, J.L. Cell Death Differ. (2004) [Pubmed]
  38. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. Stefanis, L., Troy, C.M., Qi, H., Shelanski, M.L., Greene, L.A. J. Neurosci. (1998) [Pubmed]
  39. A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury. Li, X., Rana, S.N., Schwacha, M.G., Chaudry, I.H., Choudhry, M.A. J. Leukoc. Biol. (2006) [Pubmed]
  40. Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons. Meller, R., Clayton, C., Torrey, D.J., Schindler, C.K., Lan, J.Q., Cameron, J.A., Chu, X.P., Xiong, Z.G., Simon, R.P., Henshall, D.C. Epilepsy Res. (2006) [Pubmed]
  41. Effect of Ginkgo biloba (EGb 761) on staurosporine-induced neuronal death and caspase activity in cortical cultured neurons. Massieu, L., Morán, J., Christen, Y. Brain Res. (2004) [Pubmed]
  42. Cold preservation of islets in UW solution--with special reference to apoptosis. Shirouzu, Y., Gu, Y., Koga, M., Sakurai, T., Qi, M., Hiura, A., Sumi, S., Inoue, K. J. Surg. Res. (2006) [Pubmed]
  43. Role of caspases in ionizing radiation-induced apoptosis in the developing cerebellum. Ferrer, I. J. Neurobiol. (1999) [Pubmed]
  44. Silica-induced apoptosis in alveolar macrophages: evidence of in vivo thiol depletion and the activation of mitochondrial pathway. Hu, S., Zhao, H., Al-Humadi, N.H., Yin, X.J., Ma, J.K. J. Toxicol. Environ. Health Part A (2006) [Pubmed]
  45. Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo. Ueno, M., Kakinuma, Y., Yuhki, K., Murakoshi, N., Iemitsu, M., Miyauchi, T., Yamaguchi, I. J. Pharmacol. Sci. (2006) [Pubmed]
  46. Castration-induced expression of caspase-1 in epithelia of accessory sex organs in male rats. Izawa, M., Kimura, M., Yamada, T., Saji, M. Asian J. Androl. (2001) [Pubmed]
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