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MeSH Review

Granulosa Cells

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Disease relevance of Granulosa Cells


Psychiatry related information on Granulosa Cells

  • It is concluded from the current study that IL-1 beta is a mediator of MMPI expression as well as granulosa cell steroidogenesis, and that this cytokine has divergent actions in the presence and absence of LH [6].

High impact information on Granulosa Cells

  • Wilms' tumors from three individuals and one juvenile granulosa cell tumor demonstrate reduction to homozygosity for the mutated WT1 allele [7].
  • Growth and function of primary cultures of granulosa cells obtained from immature, hypophysectomized, estrogen-treated rats were compared in serum-containing and serum-free media [8].
  • Here we show that connexin 37 is present in gap junctions between oocyte and granulosa cells and that connexin 37-deficient mice lack mature (Graafian) follicles, fail to ovulate and develop numerous inappropriate corpora lutea [9].
  • In ovarian granulosa cells, cyclin D2 is specifically induced by FSH via a cyclic-AMP-dependent pathway, indicating that expression of the various D-type cyclins is under control of distinct intracellular signalling pathways [10].
  • We report here experiments with cultured granulosa cells which suggest that this contraceptive action of prolactin is due to its ability to interfere with the action of follicle-stimulating hormone (FSH) on the synthesis of oestrogen [11].

Chemical compound and disease context of Granulosa Cells


Biological context of Granulosa Cells


Anatomical context of Granulosa Cells


Associations of Granulosa Cells with chemical compounds


Gene context of Granulosa Cells


Analytical, diagnostic and therapeutic context of Granulosa Cells


  1. Morphology and classification of ovarian neoplasms in F344 rats and (C57BL/6 X C3H)F1 mice. Alison, R.H., Morgan, K.T., Haseman, J.K., Boorman, G.A. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. A new prostaglandin E receptor mediates calcium influx and acrosome reaction in human spermatozoa. Schaefer, M., Hofmann, T., Schultz, G., Gudermann, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Transcriptional regulation of the rat tissue type plasminogen activator gene: localization of DNA elements and nuclear factors mediating constitutive and cyclic AMP-induced expression. Ohlsson, M., Leonardsson, G., Jia, X.C., Feng, P., Ny, T. Mol. Cell. Biol. (1993) [Pubmed]
  4. Effect of cyclophosphamide on the immature rat ovary. Ataya, K.M., Valeriote, F.A., Ramahi-Ataya, A.J. Cancer Res. (1989) [Pubmed]
  5. Analysis of WT1 in granulosa cell and other sex cord-stromal tumors. Coppes, M.J., Ye, Y., Rackley, R., Zhao, X.L., Liefers, G.J., Casey, G., Williams, B.R. Cancer Res. (1993) [Pubmed]
  6. Divergent effects of interleukin-1 beta on steroidogenesis and matrix metalloproteinase inhibitor expression and activity in cultured rat granulosa cells. Nothnick, W.B., Curry, T.E. Endocrinology (1996) [Pubmed]
  7. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Pelletier, J., Bruening, W., Kashtan, C.E., Mauer, S.M., Manivel, J.C., Striegel, J.E., Houghton, D.C., Junien, C., Habib, R., Fouser, L. Cell (1991) [Pubmed]
  8. Serum suppresses the expression of hormonally induced functions in cultured granulosa cells. Orly, J., Sato, G., Erickson, G.F. Cell (1980) [Pubmed]
  9. Female infertility in mice lacking connexin 37. Simon, A.M., Goodenough, D.A., Li, E., Paul, D.L. Nature (1997) [Pubmed]
  10. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Sicinski, P., Donaher, J.L., Geng, Y., Parker, S.B., Gardner, H., Park, M.Y., Robker, R.L., Richards, J.S., McGinnis, L.K., Biggers, J.D., Eppig, J.J., Bronson, R.T., Elledge, S.J., Weinberg, R.A. Nature (1996) [Pubmed]
  11. Prolactin inhibits oestrogen synthesis in the ovary. Dorrington, J., Gore-Langton, R.E. Nature (1981) [Pubmed]
  12. Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis. Veldhuis, J.D., Rodgers, R.J., Hewlett, E.L. Mol. Endocrinol. (1988) [Pubmed]
  13. Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone. Shiota, M., Tanihiro, T., Nakagawa, Y., Aoki, N., Ishida, N., Miyazaki, K., Ullrich, A., Miyazaki, H. Mol. Endocrinol. (2003) [Pubmed]
  14. In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells. Barreca, A., Artini, P.G., Del Monte, P., Ponzani, P., Pasquini, P., Cariola, G., Volpe, A., Genazzani, A.R., Giordano, G., Minuto, F. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  15. The involvement of inositol phosphoglycan mediators in the modulation of steroidogenesis by insulin and insulin-like growth factor-I. Romero, G., Garmey, J.C., Veldhuis, J.D. Endocrinology (1993) [Pubmed]
  16. Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Billig, H., Furuta, I., Hsueh, A.J. Endocrinology (1993) [Pubmed]
  17. Human chorionic gonadotropin and 8-bromo cyclic adenosine monophosphate promote an acute increase in cytochrome P450scc and adrenodoxin messenger RNAs in cultured human granulosa cells by a cycloheximide-insensitive mechanism. Golos, T.G., Miller, W.L., Strauss, J.F. J. Clin. Invest. (1987) [Pubmed]
  18. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu, I., Suh, B.S., Himmelhoch, S., Amsterdam, A. J. Cell Biol. (1990) [Pubmed]
  19. Uptake of gold- and [3H]cholesteryl linoleate-labeled human low density lipoprotein by cultured rat granulosa cells: cellular mechanisms involved in lipoprotein metabolism and their importance to steroidogenesis. Paavola, L.G., Strauss, J.F., Boyd, C.O., Nestler, J.E. J. Cell Biol. (1985) [Pubmed]
  20. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu, S.Y., Kaipia, A., McGee, E., Lomeli, M., Hsueh, A.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis. Otsuka, F., Shimasaki, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  22. Gonadotropin-releasing hormone analogue binds to luteal cells and inhibits progesterone production. Clayton, R.N., Harwood, J.P., Catt, K.J. Nature (1979) [Pubmed]
  23. A time-lapse video image intensification analysis of cytoplasmic organelle movements during endosome translocation. Herman, B., Albertini, D.F. J. Cell Biol. (1984) [Pubmed]
  24. A functional bone morphogenetic protein system in the ovary. Shimasaki, S., Zachow, R.J., Li, D., Kim, H., Iemura, S., Ueno, N., Sampath, K., Chang, R.J., Erickson, G.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. Secretion of follicle-stimulating hormone and production of inhibin are reciprocally related. Ying, S.Y., Czvik, J., Becker, A., Ling, N., Ueno, N., Guillemin, R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  26. Granulosa cell tumor of the ovary. Schumer, S.T., Cannistra, S.A. J. Clin. Oncol. (2003) [Pubmed]
  27. Oestrogens regulate divergent effects of prolactin in the ovary. Veldhuis, J.D., Hammond, J.M. Nature (1980) [Pubmed]
  28. Transmission of hormonal stimulation by cell-to-cell communication. Lawrence, T.S., Beers, W.H., Gilula, N.B. Nature (1978) [Pubmed]
  29. Gonadotropin releasing hormone agonists stimulate meiotic maturation of follicle-enclosed rat oocytes in vitro. Hillensjö, T., LeMaire, W.J. Nature (1980) [Pubmed]
  30. Intragonadal regulation of follicular maturation. Tonetta, S.A., diZerega, G.S. Endocr. Rev. (1989) [Pubmed]
  31. Gonadotropin-releasing hormone: regulation of adenosine 3',5'-monophosphate in ovarian granulosa cells. Knecht, M., Catt, K.J. Science (1981) [Pubmed]
  32. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Robker, R.L., Russell, D.L., Espey, L.L., Lydon, J.P., O'Malley, B.W., Richards, J.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  33. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Di Pasquale, E., Beck-Peccoz, P., Persani, L. Am. J. Hum. Genet. (2004) [Pubmed]
  34. Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway. Elvin, J.A., Yan, C., Matzuk, M.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  35. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes. Mulsant, P., Lecerf, F., Fabre, S., Schibler, L., Monget, P., Lanneluc, I., Pisselet, C., Riquet, J., Monniaux, D., Callebaut, I., Cribiu, E., Thimonier, J., Teyssier, J., Bodin, L., Cognié, Y., Chitour, N., Elsen, J.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  36. Expression and localization of inducible and endothelial nitric oxide synthase in the rat ovary. Effects of gonadotropin stimulation in vivo. Van Voorhis, B.J., Moore, K., Strijbos, P.J., Nelson, S., Baylis, S.A., Grzybicki, D., Weiner, C.P. J. Clin. Invest. (1995) [Pubmed]
  37. Ovarian stimulation and granulosa-cell tumour. Willemsen, W., Kruitwagen, R., Bastiaans, B., Hanselaar, T., Rolland, R. Lancet (1993) [Pubmed]
  38. Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Boerboom, D., Paquet, M., Hsieh, M., Liu, J., Jamin, S.P., Behringer, R.R., Sirois, J., Taketo, M.M., Richards, J.S. Cancer Res. (2005) [Pubmed]
  39. Tumor necrosis factor alpha inhibits transcriptional activity of the porcine P-45011A insulin-like growth factor response element. Urban, R.J., Nagamani, M., Bodenburg, Y. J. Biol. Chem. (1996) [Pubmed]
  40. Isolation and biochemical characterization of ten-nanometer filaments from cultured ovarian granulosa cells. Albertini, D.F., Kravit, N.G. J. Biol. Chem. (1981) [Pubmed]
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