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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Granulosa Cells

 
 
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Disease relevance of Granulosa Cells

 

Psychiatry related information on Granulosa Cells

  • It is concluded from the current study that IL-1 beta is a mediator of MMPI expression as well as granulosa cell steroidogenesis, and that this cytokine has divergent actions in the presence and absence of LH [6].
 

High impact information on Granulosa Cells

  • Wilms' tumors from three individuals and one juvenile granulosa cell tumor demonstrate reduction to homozygosity for the mutated WT1 allele [7].
  • Growth and function of primary cultures of granulosa cells obtained from immature, hypophysectomized, estrogen-treated rats were compared in serum-containing and serum-free media [8].
  • Here we show that connexin 37 is present in gap junctions between oocyte and granulosa cells and that connexin 37-deficient mice lack mature (Graafian) follicles, fail to ovulate and develop numerous inappropriate corpora lutea [9].
  • In ovarian granulosa cells, cyclin D2 is specifically induced by FSH via a cyclic-AMP-dependent pathway, indicating that expression of the various D-type cyclins is under control of distinct intracellular signalling pathways [10].
  • We report here experiments with cultured granulosa cells which suggest that this contraceptive action of prolactin is due to its ability to interfere with the action of follicle-stimulating hormone (FSH) on the synthesis of oestrogen [11].
 

Chemical compound and disease context of Granulosa Cells

 

Biological context of Granulosa Cells

 

Anatomical context of Granulosa Cells

 

Associations of Granulosa Cells with chemical compounds

 

Gene context of Granulosa Cells

 

Analytical, diagnostic and therapeutic context of Granulosa Cells

References

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  2. A new prostaglandin E receptor mediates calcium influx and acrosome reaction in human spermatozoa. Schaefer, M., Hofmann, T., Schultz, G., Gudermann, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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  6. Divergent effects of interleukin-1 beta on steroidogenesis and matrix metalloproteinase inhibitor expression and activity in cultured rat granulosa cells. Nothnick, W.B., Curry, T.E. Endocrinology (1996) [Pubmed]
  7. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Pelletier, J., Bruening, W., Kashtan, C.E., Mauer, S.M., Manivel, J.C., Striegel, J.E., Houghton, D.C., Junien, C., Habib, R., Fouser, L. Cell (1991) [Pubmed]
  8. Serum suppresses the expression of hormonally induced functions in cultured granulosa cells. Orly, J., Sato, G., Erickson, G.F. Cell (1980) [Pubmed]
  9. Female infertility in mice lacking connexin 37. Simon, A.M., Goodenough, D.A., Li, E., Paul, D.L. Nature (1997) [Pubmed]
  10. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Sicinski, P., Donaher, J.L., Geng, Y., Parker, S.B., Gardner, H., Park, M.Y., Robker, R.L., Richards, J.S., McGinnis, L.K., Biggers, J.D., Eppig, J.J., Bronson, R.T., Elledge, S.J., Weinberg, R.A. Nature (1996) [Pubmed]
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  14. In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells. Barreca, A., Artini, P.G., Del Monte, P., Ponzani, P., Pasquini, P., Cariola, G., Volpe, A., Genazzani, A.R., Giordano, G., Minuto, F. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
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  19. Uptake of gold- and [3H]cholesteryl linoleate-labeled human low density lipoprotein by cultured rat granulosa cells: cellular mechanisms involved in lipoprotein metabolism and their importance to steroidogenesis. Paavola, L.G., Strauss, J.F., Boyd, C.O., Nestler, J.E. J. Cell Biol. (1985) [Pubmed]
  20. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu, S.Y., Kaipia, A., McGee, E., Lomeli, M., Hsueh, A.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis. Otsuka, F., Shimasaki, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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  28. Transmission of hormonal stimulation by cell-to-cell communication. Lawrence, T.S., Beers, W.H., Gilula, N.B. Nature (1978) [Pubmed]
  29. Gonadotropin releasing hormone agonists stimulate meiotic maturation of follicle-enclosed rat oocytes in vitro. Hillensjö, T., LeMaire, W.J. Nature (1980) [Pubmed]
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  32. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Robker, R.L., Russell, D.L., Espey, L.L., Lydon, J.P., O'Malley, B.W., Richards, J.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  33. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Di Pasquale, E., Beck-Peccoz, P., Persani, L. Am. J. Hum. Genet. (2004) [Pubmed]
  34. Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway. Elvin, J.A., Yan, C., Matzuk, M.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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  38. Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Boerboom, D., Paquet, M., Hsieh, M., Liu, J., Jamin, S.P., Behringer, R.R., Sirois, J., Taketo, M.M., Richards, J.S. Cancer Res. (2005) [Pubmed]
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