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Chemical Compound Review

Thiomalate     2-sulfanylbutanedioic acid

Synonyms: HSTM, Thiomalic acid, M6182_ALDRICH, NSC-7302, USAF M-2, ...
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Disease relevance of Monomercaptosuccinic acid


High impact information on Monomercaptosuccinic acid


Chemical compound and disease context of Monomercaptosuccinic acid


Biological context of Monomercaptosuccinic acid


Anatomical context of Monomercaptosuccinic acid


Associations of Monomercaptosuccinic acid with other chemical compounds


Gene context of Monomercaptosuccinic acid


Analytical, diagnostic and therapeutic context of Monomercaptosuccinic acid

  • Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection [30].
  • Intramuscular injection of the purified drug to 2 healthy subjects produced easily detectable levels of thiomalate in both plasma and urine; 7.7 and 9.8% respectively of the doses given were recovered in urine as free thomalate within 4 h [31].
  • Sodium thiosulfate, auranofin and sodium thiomalate gave positive patch test reactions [32].
  • The complex formation of thiomalic acid (H3L) with Hg(II) and Pb(II) was investigated under physiological conditions of 37 degrees C and 0.15 mol dm-3 NaCl by potentiometric titrations using glass electrodes [33].
  • It has been proposed that this activity may be used for nonimmune drug targeting to sites in the extra-cellular matrix such as the targeting of gold thiomalate to rheumatoid joints [34].


  1. Acidosis potentiates oxidative neuronal death by multiple mechanisms. Ying, W., Han, S.K., Miller, J.W., Swanson, R.A. J. Neurochem. (1999) [Pubmed]
  2. Different effects of two gold compounds on muscle contraction, membrane potential and ryanodine receptor. Oba, T., Ishikawa, T., Yamaguchi, M. Eur. J. Pharmacol. (1999) [Pubmed]
  3. Growth studies on xenic cultures of Entamoeba gingivalis using established media. Gannon, J.T., Linke, H.A. Int. J. Parasitol. (1989) [Pubmed]
  4. Erythema annulare centrifugum associated with gold sodium thiomalate therapy. Tsuji, T., Nishimura, M., Kimura, S. J. Am. Acad. Dermatol. (1992) [Pubmed]
  5. A multicentre double-blind comparison of auranofin, intramuscular gold thiomalate and placebo in patients with psoriatic arthritis. Palit, J., Hill, J., Capell, H.A., Carey, J., Daunt, S.O., Cawley, M.I., Bird, H.A., Nuki, G. Br. J. Rheumatol. (1990) [Pubmed]
  6. Effect of gold sodium thiomalate and its thiomalate component on the in vitro expression of endothelial cell adhesion molecules. Newman, P.M., To, S.S., Robinson, B.G., Hyland, V.J., Schrieber, L. J. Clin. Invest. (1994) [Pubmed]
  7. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Jing, Y., Dai, J., Chalmers-Redman, R.M., Tatton, W.G., Waxman, S. Blood (1999) [Pubmed]
  8. Adverse immune reactions to gold. I. Chronic treatment with an Au(I) drug sensitizes mouse T cells not to Au(I), but to Au(III) and induces autoantibody formation. Schuhmann, D., Kubicka-Muranyi, M., Mirtschewa, J., Günther, J., Kind, P., Gleichmann, E. J. Immunol. (1990) [Pubmed]
  9. Mechanism of selenium-glutathione peroxidase and its inhibition by mercaptocarboxylic acids and other mercaptans. Chaudiere, J., Wilhelmsen, E.C., Tappel, A.L. J. Biol. Chem. (1984) [Pubmed]
  10. The effect of gold sodium thiomalate and its constituent part, thiomalate, on the virus titres and the lysosomal enzyme activity in peritoneal macrophages of Swiss/A2G mice infected with the avirulent strain of Semliki Forest virus. Mehta, S., Webb, H.E. Journal of experimental pathology (Oxford, England) (1990) [Pubmed]
  11. The natural course of gold and penicillamine nephropathy: a longterm study of 54 patients. Hall, C.L. Adv. Exp. Med. Biol. (1989) [Pubmed]
  12. Attenuation of endogenous oxidative stress-induced cell death by cytochrome P450 inhibitors in primary cultures of rat hepatocytes. Shiba, D., Shimamoto, N. Free Radic. Biol. Med. (1999) [Pubmed]
  13. Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants. Twigg, J., Fulton, N., Gomez, E., Irvine, D.S., Aitken, R.J. Hum. Reprod. (1998) [Pubmed]
  14. NR8383 alveolar macrophage toxic growth arrest by hydrogen peroxide is associated with induction of growth-arrest and DNA damage-inducible genes GADD45 and GADD153. Patton, G.W., Paciga, J.E., Shelley, S.A. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  15. Fluorescence and interactions with thiol compounds of Nile Red-adsorbed gold nanoparticles. Lee, K.H., Chen, S.J., Jeng, J.Y., Cheng, Y.C., Shiea, J.T., Chang, H.T. Journal of colloid and interface science (2007) [Pubmed]
  16. Homology modeling and docking mechanism of the mercaptosuccinate and methotrexate to P. falciparum 1-Cys peroxiredoxin: a preliminary molecular study. Hamza, A. J. Biomol. Struct. Dyn. (2002) [Pubmed]
  17. Intracellular distribution of radiogold. Localization to large granule membranes. Penneys, N.S., McCreary, S., Gottlieb, N.L. Arthritis Rheum. (1976) [Pubmed]
  18. Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase. Ishida, Y., Nagai, A., Kobayashi, S., Kim, S.U. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  19. Cultured human cells can acquire resistance to the antiproliferative effect of sodium aurothiomalate. Glennås, A., Rugstad, H.E. Ann. Rheum. Dis. (1986) [Pubmed]
  20. Inhibition of lymphocyte activation by gold sodium thiomalate. Hopkins, S.J., Jayson, M.I., Van der Zeil, P. Br. J. Pharmacol. (1983) [Pubmed]
  21. Cultured human cells with high levels of gold-binding cytosolic metallothionein are not resistant to the growth inhibitory effect of sodium aurothiomalate. Glennås, A., Rugstad, H.E. Ann. Rheum. Dis. (1986) [Pubmed]
  22. Reversible voltage-induced assembly of au nanoparticles at liquid/liquid interfaces. Su, B., Abid, J.P., Fermín, D.J., Girault, H.H., Hoffmannová, H., Krtil, P., Samec, Z. J. Am. Chem. Soc. (2004) [Pubmed]
  23. Involvement of lipid peroxidation and organic peroxides in UVA-induced matrix metalloproteinase-1 expression. Polte, T., Tyrrell, R.M. Free Radic. Biol. Med. (2004) [Pubmed]
  24. Luminescence and stability of aqueous thioalkyl acid capped CdSe/ZnS quantum dots correlated to ligand ionization. Algar, W.R., Krull, U.J. Chemphyschem : a European journal of chemical physics and physical chemistry (2007) [Pubmed]
  25. Ascorbate synthesis-dependent glutathione consumption in mouse liver. Bánhegyi, G., Csala, M., Braun, L., Garzó, T., Mandl, J. FEBS Lett. (1996) [Pubmed]
  26. Purification and properties of a recombinant sulfur analog of murine selenium-glutathione peroxidase. Rocher, C., Lalanne, J.L., Chaudière, J. Eur. J. Biochem. (1992) [Pubmed]
  27. Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. Baud, O., Greene, A.E., Li, J., Wang, H., Volpe, J.J., Rosenberg, P.A. J. Neurosci. (2004) [Pubmed]
  28. Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation. Kandler, B., Maitz, P., Fischer, M.B., Watzek, G., Gruber, R. Bone (2005) [Pubmed]
  29. A radioassay for proteolytic cleavage of isolated cartilage proteoglycan. 2. Inhibition of human leukocyte elastase and cathepsin G by anti-inflammatory drugs. Stephens, R.W., Walton, E.A., Ghosh, P., Taylor, T.K., Gramse, M., Havemann, K. Arzneimittel-Forschung. (1980) [Pubmed]
  30. Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate. Rudge, S.R., Perrett, D., Swannell, A.J. Ann. Rheum. Dis. (1984) [Pubmed]
  31. Circulating thiomalate after administration of disodium aurothiomalate: impurity or active metabolite? Rudge, S.R., Perrett, D., Swannell, A.J., Drury, P.L. J. Rheumatol. (1984) [Pubmed]
  32. Long-lasting allergic patch test reaction caused by gold. Aro, T., Kanerva, L., Häyrinen-Immonen, R., Silvennoinen-Kassinen, S., Konttinen, Y.T., Jolanki, R., Estlander, T. Contact Derm. (1993) [Pubmed]
  33. Complexation of thiomalic acid with mercury (II) and lead (II) under physiological conditions. Maeda, M., Okada, K., Wakabayashi, K., Honda, K., Ito, K., Kinjo, Y. J. Inorg. Biochem. (1991) [Pubmed]
  34. Preparation of a gelatin-binding conjugate containing gold thiomalate. Brown, R.A., More, J., Ejim, O.S. Arzneimittel-Forschung. (1993) [Pubmed]
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