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Chemical Compound Review:

Poly(vA) 9-ethenylpurin-6-amine

Synonyms: SureCN4123842, NSC-248606, NSC248606, NSC 248606, AC1L8MT3, ...

Pitha, J. et al., Pitha, J., Yashima, E. et al.

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Disease relevance of NSC248606

The effects of poly(1-vinyluracil) [poly(vU)] and poly(9-vinyladenine) [poly(vA)] on the RNA-dependent DNA polymerase activity of murine leukemia virus (Moloney strain) were studied [1].

High impact information on NSC248606

Effects of Poly(1-vinyluracil) and Poly(9-vinyladenine) on viral RNA-directed DNA polymerase [1].
Studies on the mechanism of the inhibition using the alpha class DNA polymerase and different templates showed that the enzyme activity was inhibited in all cases where base-pairing between the vinyl polymer and the template occurred; poly(9-vinyladenine) did not interfere with the replication of templates to which it does not bind [2].

Analytical, diagnostic and therapeutic context of NSC248606

The interaction was dependent on the molecular weight of PVAd determined by uv and CD spectroscopies [3].

References

Effects of Poly(1-vinyluracil) and Poly(9-vinyladenine) on viral RNA-directed DNA polymerase. Pitha, J. Cancer Res. (1976) [Pubmed]
Template specific inhibitor of mammalian DNA polymerases. Pitha, J., Wilson, S.H. Nucleic Acids Res. (1976) [Pubmed]
Spectroscopic study of the interaction between poly-(9-vinyladenine) and single or multistrand RNA. Yashima, E., Tajima, T., Miyauchi, N., Akashi, M. Biopolymers (1992) [Pubmed]

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