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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Spectrum Analysis

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Disease relevance of Spectrum Analysis


High impact information on Spectrum Analysis

  • Indirect exchange mechanisms involving H3 intermediates have been suggested to occur as well, but these are difficult to test because bimolecular reactions cannot be studied by the femtosecond spectroscopies used to monitor unimolecular reactions [6].
  • Time domain pulsed saturation recovery and electron-electron double resonance spectroscopies were used to measure the spin-lattice relaxation rates of the electron and the nitrogen nucleus in nitroxide spin labels in liquids [7].
  • An iron(III)-tyrosinate complex was identified in ferritin by ultraviolet-visible and resonance Raman spectroscopies [8].
  • K-ras-2 polymerase chain reaction and spectrum analysis were performed using sorted DNA specific epithelial subclones [9].
  • Its Cu(II) complexes were characterized by electronic and EPR spectroscopies [10].

Chemical compound and disease context of Spectrum Analysis


Biological context of Spectrum Analysis

  • Herein, we investigated the structural stability and folding kinetics of a series of tryptophan zippers by static IR and CD spectroscopies and the IR temperature jump method [16].
  • The geometric and electronic structure of the high-spin ferric active site of protocatechuate 3,4-dioxygenase (3,4-PCD) has been examined by absorption (Abs), circular dichroism (CD), magnetic CD (MCD), and variable-temperature-variable-field (VTVH) MCD spectroscopies [17].
  • We assessed the physiologic significance of the circadian rhythm of circulating leptin using power spectrum analysis of heart rate variability (HRV) in nine cachexic male patients with COPD, eight noncachexic patients with COPD, and seven healthy control subjects [18].
  • Can(r) mutation spectrum analysis of pol32Delta strains revealed a substantial increase in the frequency of deletions and duplications (primarily deletions) of sequences flanked by short direct repeats, which appears to be RAD52 and RAD10 independent [19].
  • Power spectrum analysis of heart rate variability (PSA of HRV) is a promising method, which can be used as an index of cardiac autonomic balance [20].

Anatomical context of Spectrum Analysis


Associations of Spectrum Analysis with chemical compounds


Gene context of Spectrum Analysis

  • A combination of biochemical and spectroscopic techniques, including UV-visible absorption and 57Fe Mössbauer spectroscopies, have been used to investigate the ability of purified human Nfu to assemble Fe-S clusters [31].
  • Tumor spectrum analysis in p53-mutant mice [32].
  • We have therefore used a range of complementary spectroscopies to characterize the coordination of Cu(2+) to Abeta in solution [33].
  • Deletion of Phe44 or substitution with leucine did not significantly change the structure of hGH as determined by circular dichroism, absorbance, and fluorescence spectroscopies [34].
  • The conformation of three synthetic peptides encompassing the proximal and distal half of the third intracellular loop (Ni3 and Ci3) and a portion of the cytoplasmic tail (fCT) of the angiotensin II AT1A receptor has been studied using circular dischroism and fluorescence spectroscopies [35].

Analytical, diagnostic and therapeutic context of Spectrum Analysis


  1. Infrared and EPR studies on cyanide binding to the heme-copper binuclear center of cytochrome bo-type ubiquinol oxidase from Escherichia coli. Release of a CuB-cyano complex in the partially reduced state. Tsubaki, M., Mogi, T., Hori, H., Sato-Watanabe, M., Anraku, Y. J. Biol. Chem. (1996) [Pubmed]
  2. Resonance Raman and magnetic circular dichroism studies of reduced [2Fe-2S] proteins. Fu, W., Drozdzewski, P.M., Davies, M.D., Sligar, S.G., Johnson, M.K. J. Biol. Chem. (1992) [Pubmed]
  3. Circular dichroism and x-ray spectroscopies of Azotobacter vinelandii nitrogenase iron protein. MgATP and MgADP induced protein conformational changes affecting the [4Fe-4S] cluster and characterization of a [2Fe-2S] form. Ryle, M.J., Lanzilotta, W.N., Seefeldt, L.C., Scarrow, R.C., Jensen, G.M. J. Biol. Chem. (1996) [Pubmed]
  4. Studies of the ferredoxin from Thermus thermophilus. Hille, R., Yoshida, T., Tarr, G.E., Williams, C.H., Ludwig, M.L., Fee, J.A., Kent, T.A., Huynh, B.H., Münck, E. J. Biol. Chem. (1983) [Pubmed]
  5. Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme. Caignan, G.A., Deshmukh, R., Wilks, A., Zeng, Y., Huang, H.W., Moënne-Loccoz, P., Bunce, R.A., Eastman, M.A., Rivera, M. J. Am. Chem. Soc. (2002) [Pubmed]
  6. Observation and interpretation of a time-delayed mechanism in the hydrogen exchange reaction. Althorpe, S.C., Fernández-Alonso, F., Bean, B.D., Ayers, J.D., Pomerantz, A.E., Zare, R.N., Wrede, E. Nature (2002) [Pubmed]
  7. Molecular dynamics in liquids: spin-lattice relaxation of nitroxide spin labels. Robinson, B.H., Haas, D.A., Mailer, C. Science (1994) [Pubmed]
  8. Formation of an Fe(III)-tyrosinate complex during biomineralization of H-subunit ferritin. Waldo, G.S., Ling, J., Sanders-Loehr, J., Theil, E.C. Science (1993) [Pubmed]
  9. K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas. Giaretti, W., Pujic, N., Rapallo, A., Nigro, S., Di Vinci, A., Geido, E., Risio, M. Gastroenterology (1995) [Pubmed]
  10. Calix[6]tren and copper(II): a third generation of funnel complexes on the way to redox calix-zymes. Izzet, G., Douziech, B., Prangé, T., Tomas, A., Jabin, I., Le Mest, Y., Reinaud, O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Spectroscopic studies on the mechanism of the topa quinone generation in bacterial monoamine oxidase. Matsuzaki, R., Suzuki, S., Yamaguchi, K., Fukui, T., Tanizawa, K. Biochemistry (1995) [Pubmed]
  12. Spectral composition of synchronized discharge of phrenic nerve activity in the rabbit and effects of pulmonary afferents. Schmid, K., Böhmer, G. Respiration physiology. (1989) [Pubmed]
  13. Structure of the O-specific polysaccharide of Proteus vulgaris O25 containing 3-O-[(R)-1-carboxyethyl]-D-glucose. Knirel, Y.A., Kaca, W., Paramonov, N.A., Cedzynski, M., Vinogradov, E.V., Ziolkowski, A., Shashkov, A.S., Rozalski, A. Eur. J. Biochem. (1997) [Pubmed]
  14. Optical, EPR and Mössbauer spectroscopic studies on the NO derivatives of cytochrome cd1 from Thiobacillus denitrificans. Liu, M.C., Huynh, B.H., Payne, W.J., Peck, H.D., Dervartanian, D.V., Legall, J. Eur. J. Biochem. (1987) [Pubmed]
  15. QT interval lengthening in cardiac disease relates more to left ventricular systolic dysfunction than to autonomic function. Davey, P. Eur. J. Heart Fail. (2000) [Pubmed]
  16. Understanding the key factors that control the rate of beta-hairpin folding. Du, D., Zhu, Y., Huang, C.Y., Gai, F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  17. Spectroscopic and electronic structure studies of protocatechuate 3,4-dioxygenase: nature of tyrosinate-Fe(III) bonds and their contribution to reactivity. Davis, M.I., Orville, A.M., Neese, F., Zaleski, J.M., Lipscomb, J.D., Solomon, E.I. J. Am. Chem. Soc. (2002) [Pubmed]
  18. A novel pathophysiologic phenomenon in cachexic patients with chronic obstructive pulmonary disease: the relationship between the circadian rhythm of circulating leptin and the very low-frequency component of heart rate variability. Takabatake, N., Nakamura, H., Minamihaba, O., Inage, M., Inoue, S., Kagaya, S., Yamaki, M., Tomoike, H. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  19. Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway. Huang, M.E., Rio, A.G., Galibert, M.D., Galibert, F. Genetics (2002) [Pubmed]
  20. Power spectral analysis of heart rate variability in psychiatry. Cohen, H., Matar, M.A., Kaplan, Z., Kotler, M. Psychotherapy and psychosomatics. (1999) [Pubmed]
  21. Locations of local anesthetic dibucaine in model membranes and the interaction between dibucaine and a Na+ channel inactivation gate peptide as studied by 2H- and 1H-NMR spectroscopies. Kuroda, Y., Ogawa, M., Nasu, H., Terashima, M., Kasahara, M., Kiyama, Y., Wakita, M., Fujiwara, Y., Fujii, N., Nakagawa, T. Biophys. J. (1996) [Pubmed]
  22. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase. Hammen, P.K., Allali-Hassani, A., Hallenga, K., Hurley, T.D., Weiner, H. Biochemistry (2002) [Pubmed]
  23. Resolving receptor heterogeneity using Fourier-derived affinity spectrum analysis and LIGAND: benzodiazepine receptors in the rat spinal cord. Maguire, P.A., Mechanick, J.I., Davies, M.F., Ellis, D.M., Meredith, D.B., Loew, G.H. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  24. Cytochrome o (cyoABCDE) and d (cydAB) oxidase gene expression in Escherichia coli is regulated by oxygen, pH, and the fnr gene product. Cotter, P.A., Chepuri, V., Gennis, R.B., Gunsalus, R.P. J. Bacteriol. (1990) [Pubmed]
  25. In vivo autofluorescence spectroscopy of oral premalignant and malignant lesions: distortion of fluorescence intensity by submucous fibrosis. Tsai, T., Chen, H.M., Wang, C.Y., Tsai, J.C., Chen, C.T., Chiang, C.P. Lasers in surgery and medicine. (2003) [Pubmed]
  26. Polyproline II structure in a sequence of seven alanine residues. Shi, Z., Olson, C.A., Rose, G.D., Baldwin, R.L., Kallenbach, N.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Miniaturized metalloproteins: application to iron-sulfur proteins. Lombardi, A., Marasco, D., Maglio, O., Di Costanzo, L., Nastri, F., Pavone, V. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  28. Analysis of the L116K variant of CooA, the heme-containing CO sensor, suggests the presence of an unusual heme ligand resulting in novel activity. Youn, H., Kerby, R.L., Thorsteinsson, M.V., Clark, R.W., Burstyn, J.N., Roberts, G.P. J. Biol. Chem. (2002) [Pubmed]
  29. Thioureas react with superoxide radicals to yield a sulfhydryl compound. Explanation for protective effect against paraquat. Kelner, M.J., Bagnell, R., Welch, K.J. J. Biol. Chem. (1990) [Pubmed]
  30. Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase. Inuzuka, T., Yun, B.G., Ishikawa, H., Takahashi, S., Hori, H., Matts, R.L., Ishimori, K., Morishima, I. J. Biol. Chem. (2004) [Pubmed]
  31. Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Tong, W.H., Jameson, G.N., Huynh, B.H., Rouault, T.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  32. Tumor spectrum analysis in p53-mutant mice. Jacks, T., Remington, L., Williams, B.O., Schmitt, E.M., Halachmi, S., Bronson, R.T., Weinberg, R.A. Curr. Biol. (1994) [Pubmed]
  33. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques. Syme, C.D., Nadal, R.C., Rigby, S.E., Viles, J.H. J. Biol. Chem. (2004) [Pubmed]
  34. Identification of a motif associated with the lactogenic actions of human growth hormone. Peterson, F.C., Brooks, C.L. J. Biol. Chem. (1997) [Pubmed]
  35. Conformational flexibility of three cytoplasmic segments of the angiotensin II AT1A receptor: a circular dichroism and fluorescence spectroscopy study. Pertinhez, T.A., Krybus, R., Cilli, E.M., Paivac, A.C., Nakaie, C.R., Franzoni, L., Sartor, G., Spisni, A., Schreier, S. J. Pept. Sci. (2002) [Pubmed]
  36. Keeping calcium in its place: Ca(2+)-ATPase and phospholamban. Stokes, D.L. Curr. Opin. Struct. Biol. (1997) [Pubmed]
  37. Y13C Azotobacter vinelandii ferredoxin I. A designed [Fe-S] ligand motif contains a cysteine persulfide. Kemper, M.A., Stout, C.D., Lloyd, S.J., Prasad, G.S., Fawcett, S.E., Armstrong, F.A., Shen, B., Burgess, B.K., Lloyd, S.E., Fawcett, S. J. Biol. Chem. (1997) [Pubmed]
  38. Shell click-crosslinked (SCC) nanoparticles: a new methodology for synthesis and orthogonal functionalization. Joralemon, M.J., O'Reilly, R.K., Hawker, C.J., Wooley, K.L. J. Am. Chem. Soc. (2005) [Pubmed]
  39. Tyrosine and carboxyl protonation changes in the bacteriorhodopsin photocycle. 2. Tyrosines-26 and -64. Roepe, P., Scherrer, P., Ahl, P.L., Das Gupta, S.K., Bogomolni, R.A., Herzfeld, J., Rothschild, K.J. Biochemistry (1987) [Pubmed]
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