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Chemical Compound Review:

DL-Canaline 2-amino-4-aminooxy-butanoic acid

Synonyms: NSC-80847, NSC80847, CTK8G7604, AC1N9TH4, 2-amino-4-aminooxybutanoic acid

Gafan, C. et al., Williamson, J.D. et al., Berger, L.C. et al., van Balgooy, J.N., Swaffar, D.S. et al., et al.

Swaffar, Ang,

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Disease relevance of Canaline

Thus, the replication of vaccinia virus is sensitive to inhibition by canaline at an early and a late stage in the replication cycle [1].

High impact information on Canaline

Canaline was also found to be an uncompetitive inhibitor of the plasmodial aspartate aminotransferase, with a K(i) of 27 microm [2].
The OCT of kidney bean showed a very low activity towards canaline [3].
The effect of canaline on some events in vaccinia virus replication [1].
The aminooxy analogue of ornithine, canaline, was found to inhibit the ornithine aminotransferase uncompetatively with a Ki of 492+/-98 nM [4].
Hydrolytic cleavage of CAV to canaline (CAN) and urea is mediated by arginase [5].

Associations of Canaline with other chemical compounds

Separation of canavanine and canaline by high performance liquid chromatography [6].

References

The effect of canaline on some events in vaccinia virus replication. Williamson, J.D., Archard, L.C. J. Gen. Virol. (1976) [Pubmed]
Methionine regeneration and aspartate aminotransferase in parasitic protozoa. Berger, L.C., Wilson, J., Wood, P., Berger, B.J. J. Bacteriol. (2001) [Pubmed]
Purification of ornithine carbamoyltransferase from kidney bean (Phaseolus vulgaris L.) leaves and comparison of the properties of the enzyme from canavanine-containing and -deficient plants. Lee, Y., Jun, B.O., Kim, S.G., Kwon, Y.M. Planta (1998) [Pubmed]
Characterization of the ornithine aminotransferase from Plasmodium falciparum. Gafan, C., Wilson, J., Berger, L.C., Berger, B.J. Mol. Biochem. Parasitol. (2001) [Pubmed]
Growth inhibitory effect of L-canavanine against MIA PaCa-2 pancreatic cancer cells is not due to conversion to its toxic metabolite canaline. Swaffar, D.S., Ang, C.Y. Anticancer Drugs (1999) [Pubmed]
Separation of canavanine and canaline by high performance liquid chromatography. van Balgooy, J.N. Experientia (1987) [Pubmed]

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