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Gene Review

ARG1  -  arginase 1

Homo sapiens

Synonyms: Arginase-1, Liver-type arginase, Type I arginase
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Disease relevance of ARG1


Psychiatry related information on ARG1


High impact information on ARG1

  • Human carbonic anhydrase II and rat liver arginase serve as well-studied paradigms of zinc and manganese metalloenzymes, respectively [10].
  • Toadfish synthesize urea using enzymes and subcellular distributions similar to those of elasmobranchs: glutamine-dependent carbamoyl phosphate synthethase (CPS III) and mitochondrial arginase [11].
  • Gcn5p also enhances H3-K4 trimethylation in the ARG1 ORF and bulk histones [12].
  • Unexpectedly, H3 acetylation in ARG1 coding sequences does not increase during induction due to the opposing activities of multiple HDAs associated with the ORF [12].
  • In particular, sildenafil, down-regulates arginase 1 and nitric oxide synthase-2 expression, thereby reducing the suppressive machinery of CD11b(+)/Gr-1(+) myeloid-derived suppressor cells (MDSCs) recruited by growing tumors [13].

Chemical compound and disease context of ARG1


Biological context of ARG1


Anatomical context of ARG1


Associations of ARG1 with chemical compounds


Regulatory relationships of ARG1


Other interactions of ARG1


Analytical, diagnostic and therapeutic context of ARG1


  1. Arginase in glomerulonephritis. Waddington, S.N. Kidney Int. (2002) [Pubmed]
  2. Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. Mavri-Damelin, D., Eaton, S., Damelin, L.H., Rees, M., Hodgson, H.J., Selden, C. Int. J. Biochem. Cell Biol. (2007) [Pubmed]
  3. Hyperargininemia due to liver arginase deficiency. Crombez, E.A., Cederbaum, S.D. Mol. Genet. Metab. (2005) [Pubmed]
  4. Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. Uchino, T., Haraguchi, Y., Aparicio, J.M., Mizutani, N., Higashikawa, M., Naitoh, H., Mori, M., Matsuda, I. Am. J. Hum. Genet. (1992) [Pubmed]
  5. Arginase-boronic acid complex highlights a physiological role in erectile function. Cox, J.D., Kim, N.N., Traish, A.M., Christianson, D.W. Nat. Struct. Biol. (1999) [Pubmed]
  6. Arginase: structure, mechanism, and physiological role in male and female sexual arousal. Christianson, D.W. Acc. Chem. Res. (2005) [Pubmed]
  7. A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation. Boles, R.G., Stone, M.L. Mol. Genet. Metab. (2006) [Pubmed]
  8. Effect of psychological stress on the L-arginine-nitric oxide pathway and semen quality. Eskiocak, S., Gozen, A.S., Taskiran, A., Kilic, A.S., Eskiocak, M., Gulen, S. Braz. J. Med. Biol. Res. (2006) [Pubmed]
  9. Measurement of erythrocyte arginase activity and the effect of lead on the activity in vitro. Fukumoto, K., Horiguchi, S., Nishikawa, Y. Osaka city medical journal. (1989) [Pubmed]
  10. Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes. Christianson, D.W., Cox, J.D. Annu. Rev. Biochem. (1999) [Pubmed]
  11. Evolution of urea synthesis in vertebrates: the piscine connection. Mommsen, T.P., Walsh, P.J. Science (1989) [Pubmed]
  12. Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Govind, C.K., Zhang, F., Qiu, H., Hofmeyer, K., Hinnebusch, A.G. Mol. Cell (2007) [Pubmed]
  13. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., Dolcetti, L., Bronte, V., Borrello, I. J. Exp. Med. (2006) [Pubmed]
  14. Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis. Yang, L., Lewis, C.M., Chandrasekharan, U.M., Kinney, C.M., Dicorleto, P.E., Kashyap, V.S. J. Am. Coll. Surg. (2006) [Pubmed]
  15. Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis. Schnorr, O., Schuier, M., Kagemann, G., Wolf, R., Walz, M., Ruzicka, T., Mayatepek, E., Laryea, M., Suschek, C.V., Kolb-Bachofen, V., Sies, H. Free Radic. Biol. Med. (2005) [Pubmed]
  16. A genetic map of Gibberella fujikuroi mating population A (Fusarium moniliforme). Xu, J.R., Leslie, J.F. Genetics (1996) [Pubmed]
  17. The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines. Thomasset, N., Quash, G.A., Doré, J.F. FEBS Lett. (1982) [Pubmed]
  18. Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema. Picker, J.D., Puga, A.C., Levy, H.L., Marsden, D., Shih, V.E., Degirolami, U., Ligon, K.L., Cederbaum, S.D., Kern, R.M., Cox, G.F. J. Pediatr. (2003) [Pubmed]
  19. The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23. Sparkes, R.S., Dizikes, G.J., Klisak, I., Grody, W.W., Mohandas, T., Heinzmann, C., Zollman, S., Lusis, A.J., Cederbaum, S.D. Am. J. Hum. Genet. (1986) [Pubmed]
  20. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. Li, H., Romieu, I., Sienra-Monge, J.J., Ramirez-Aguilar, M., Estela Del Rio-Navarro, B., Kistner, E.O., Gjessing, H.K., Lara-Sanchez, I.d.e.l. .C., Chiu, G.Y., London, S.J. J. Allergy Clin. Immunol. (2006) [Pubmed]
  21. Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. Pellagatti, A., Esoof, N., Watkins, F., Langford, C.F., Vetrie, D., Campbell, L.J., Fidler, C., Cavenagh, J.D., Eagleton, H., Gordon, P., Woodcock, B., Pushkaran, B., Kwan, M., Wainscoat, J.S., Boultwood, J. Br. J. Haematol. (2004) [Pubmed]
  22. Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Meurs, H., Maarsingh, H., Zaagsma, J. Trends Pharmacol. Sci. (2003) [Pubmed]
  23. Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. Topal, J.L., Brunet, A., Walch, L., Boucher, J.L., David-Dufilho, M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  24. Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide. Corraliza, I., Moncada, S. J. Rheumatol. (2002) [Pubmed]
  25. Identification of arginase in human placental villi. Ishikawa, T., Harada, T., Koi, H., Kubota, T., Azuma, H., Aso, T. Placenta (2007) [Pubmed]
  26. Further characterization of auxin-regulated mRNAs in hypocotyl sections of mung bean [Vigna radiata (L.) Wilczek]: sequence homology to genes for fatty-acid desaturases and atypical late-embryogenesis-abundant protein, and the mode of expression of the mRNAs. Yamamoto, K.T. Planta (1994) [Pubmed]
  27. Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. Jacobsen, L.C., Theilgaard-Mönch, K., Christensen, E.I., Borregaard, N. Blood (2007) [Pubmed]
  28. Pegylated Recombinant Human Arginase (rhArg-peg5,000mw) Inhibits the In vitro and In vivo Proliferation of Human Hepatocellular Carcinoma through Arginine Depletion. Cheng, P.N., Lam, T.L., Lam, W.M., Tsui, S.M., Cheng, A.W., Lo, W.H., Leung, Y.C. Cancer Res. (2007) [Pubmed]
  29. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Steppan, J., Ryoo, S., Schuleri, K.H., Gregg, C., Hasan, R.K., White, A.R., Bugaj, L.J., Khan, M., Santhanam, L., Nyhan, D., Shoukas, A.A., Hare, J.M., Berkowitz, D.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness. Yang, M., Rangasamy, D., Matthaei, K.I., Frew, A.J., Zimmmermann, N., Mahalingam, S., Webb, D.C., Tremethick, D.J., Thompson, P.J., Hogan, S.P., Rothenberg, M.E., Cowden, W.B., Foster, P.S. J. Immunol. (2006) [Pubmed]
  31. Involvement of arginase in regulating myometrial contractions during gestation in the rat. Hirata, M., Obayashi, S., Sakamoto, S., Aso, T., Imamura, M., Azuma, H. Mol. Hum. Reprod. (2006) [Pubmed]
  32. Regulation of arginase expression by T-helper II cytokines and isoproterenol. Barksdale, A.R., Bernard, A.C., Maley, M.E., Gellin, G.L., Kearney, P.A., Boulanger, B.R., Tsuei, B.J., Ochoa, J.B. Surgery (2004) [Pubmed]
  33. Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1. Carvalho, B., Seruca, R., Carneiro, F., Buys, C.H., Kok, K. Genes Chromosomes Cancer (1999) [Pubmed]
  34. Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. Christiansen, B., Wellendorph, P., Bräuner-Osborne, H. Br. J. Pharmacol. (2006) [Pubmed]
  35. Anti-CYP2D6 antibodies detected by quantitative radioligand assay and relation to antibodies to liver-specific arginase in patients with autoimmune hepatitis. Kimura, M., Tatsumi, K.I., Tada, H., Izumi, Y., Kaneko, A., Kato, M., Masuzawa, M., Ikemoto, M., Yabusaki, Y., Hidaka, Y., Amino, N. Clin. Chim. Acta (2002) [Pubmed]
  36. Molecular genetic study of human arginase deficiency. Grody, W.W., Klein, D., Dodson, A.E., Kern, R.M., Wissmann, P.B., Goodman, B.K., Bassand, P., Marescau, B., Kang, S.S., Leonard, J.V. Am. J. Hum. Genet. (1992) [Pubmed]
  37. Insights into the interaction of human liver arginase with tightly and weakly bound manganese ions by chemical modification and site-directed mutagenesis studies. Orellana, M.S., López, V., Uribe, E., Fuentes, M., Salas, M., Carvajal, N. Arch. Biochem. Biophys. (2002) [Pubmed]
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