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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

C00744     2- [(2R,3R,9R,11R,12R,13S,14R)- 12-[(2S,3R...

Synonyms:
 
 
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Disease relevance of C00744

 

High impact information on C00744

  • 5. The enzyme required Mg2+, Mn2+, or Co2+ for maximal activity and was catalytically optimal at pH 7.5-8.0 and 31 degrees C. The O-methyltransferase catalyzed the conversion of macrocin to tylosin at a stoichiometric ratio of 1:1 [2].
  • 0. The enzyme required Mg2+ for maximal activity and was catalytically optimal at pH 7.8-8.5 and 42 degrees C. The O-methyltransferase catalyzed conversion of demethylmacrocin to macrocin at a stoichiometric ratio of 1:1 [1].
  • A high-performance liquid chromatographic (HPLC) procedure was developed to assay S-adenosyl-L-methionine: macrocin O-methyltransferase [3].
  • We have shown that a mutant blocked in hydroxylation of the C-20 methyl group is also blocked in the further dehydrogenation of the C-20 hydroxymethyl group to a formyl group, and have confirmed in in vitro studies that the 2"'-O-methylation of demethylmacrocin must proceed the 3"'-O-methylation of macrocin to produce tylosin [4].
  • Antimicrobial activity of tylosin (CAS 1401-69-0) and five other 16-membered macrolides biosynthesized by Streptomyces fradiae (lactenocin, desmycosin, macrosin (CAS 11049-15-3), relomycin (CAS 1404-48-4) and 5-O-mycaminosyl tylonolide) against Ureaplasma urealyticum was studied [5].
 

Chemical compound and disease context of C00744

  • S-Adenosyl-L-methionine:macrocin O-methyltransferase catalyzes conversion of macrocin to tylosin, the terminal and main rate-limiting step of tylosin biosynthesis in Streptomyces fradiae [2].

References

 
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