Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Carminomycinol (9R)-7-(4-amino-5-hydroxy-6- methyl-oxan-2...

Synonyms: AC1L2ATU, LS-86969, RP-32999, 62182-86-9, Antibiotic 32999RP, ...

Reich, S.D. et al., Comis, R.L. et al.

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Disease relevance of Carminomycinol

Since carminomycinol has antitumor activity and host toxicity, this metabolite may play an important role in the efficacy and toxicity of carminomycin therapy [1].

High impact information on Carminomycinol

CMN was found to be a more potent inhibitor of human granulocyte-macrophage colony-forming units than was carminomycinol [2].

References

Pharmacokinetics of carminomycin in dogs and humans. Preliminary report. Reich, S.D., Fandrich, S.E., Finkelstein, T.T., Schurig, J.E., Florczyk, A.P., Comis, R.L., Crooke, S.T. Cancer Chemother. Pharmacol. (1981) [Pubmed]
A phase I and clinical pharmacology study of intravenously administered carminomycin in cancer patients in the United States. Comis, R.L., Issell, B.F., Pittman, K., Ginsberg, S.J., Rudolph, A., Aust, J.C., DiFino, S.M., Tinsley, R.W., Poiesz, B.J., Crooke, S.T. Cancer Res. (1982) [Pubmed]

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