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Chemical Compound Review

AC1L9828     [(2R,3S,4R)-5-[9-[(3R,4S,5R)- 3,4-dihydroxy...

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Disease relevance of phosphoribosyl-ATP

  • Neonatal diabetes was associated with the Wolcott-Rallison syndrome in six infants, hyperuricemia due to phosphoribosyl-ATP pyrophosphatase hyperactivity in two, and celiac disease in two [1].
  • Structure-guided analysis of the new dimeric dUTPase family revealed its sequence relationship to the phage T4 dCTPase, phosphoribosyl-ATP pyrophosphatase HisE, NTP pyrophosphatase MazG, and several uncharacterized protein families, including the human protein XTP3TPA (RS21-C6), which is overexpressed in embryonic and cancer cells [2].

High impact information on phosphoribosyl-ATP


  1. Long-term course of neonatal diabetes. von Mühlendahl, K.E., Herkenhoff, H. N. Engl. J. Med. (1995) [Pubmed]
  2. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. Moroz, O.V., Murzin, A.G., Makarova, K.S., Koonin, E.V., Wilson, K.S., Galperin, M.Y. J. Mol. Biol. (2005) [Pubmed]
  3. Cloning and sequence of a 3.835 kbp DNA fragment containing the HIS4 gene and a fragment of a PEX5-like gene from Candida albicans. Navarro-García, F., Pérez-Díaz, R.M., Negredo, A.I., Pla, J., Nombela, C. Yeast (1998) [Pubmed]
  4. Kinetic properties of ATP phosphoribosyltransferase of Escherichia coli. Tébar, A.R., Ballesteros, A.O. Mol. Cell. Biochem. (1976) [Pubmed]
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