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MeSH Review

Celiac Disease

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Disease relevance of Celiac Disease


Psychiatry related information on Celiac Disease


High impact information on Celiac Disease


Chemical compound and disease context of Celiac Disease


Biological context of Celiac Disease


Anatomical context of Celiac Disease


Gene context of Celiac Disease

  • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease [24].
  • Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene [25].
  • Immunoglobulin allotype markers and HLA-A, HLA-B, and HLA-DR locus antigens were determined in 30 White patients with gluten-sensitive enteropathy and 30 controls matched for age, ethnic background, and geographic origin [26].
  • Celiac disease (CD) is characterized by autodestruction of enterocytes after exposure of genetically susceptible individuals to dietary gluten [27].
  • In the celiac disease group, MSI-H was associated with loss of hMLH1 and hMSH2 in 6 and 1 specimens, respectively [28].

Analytical, diagnostic and therapeutic context of Celiac Disease


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  2. Chlorpropamide-induced hypoglycemia. A dramatic presentation of celiac disease. Rosenbaum, L.H., Rosenbaum, H. JAMA (1982) [Pubmed]
  3. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Askling, J., Linet, M., Gridley, G., Halstensen, T.S., Ekström, K., Ekbom, A. Gastroenterology (2002) [Pubmed]
  4. Circulating antibodies to bovine albumin in ulcerative colitis and Crohn's disease. Characterization of the antibody response. Falchuk, K.R., Isselbacher, K.J. Gastroenterology (1976) [Pubmed]
  5. Celiac disease, brain atrophy, and dementia. Collin, P., Pirttilä, T., Nurmikko, T., Somer, H., Erilä, T., Keyriläinen, O. Neurology (1991) [Pubmed]
  6. Mechanisms by which nutritional disorders cause reduced bone mass in adults. Miller, K.K. Journal of women's health (2002) (2003) [Pubmed]
  7. Molecular basis of celiac disease. Sollid, L.M. Annu. Rev. Immunol. (2000) [Pubmed]
  8. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Monsuur, A.J., de Bakker, P.I., Alizadeh, B.Z., Zhernakova, A., Bevova, M.R., Strengman, E., Franke, L., van't Slot, R., van Belzen, M.J., Lavrijsen, I.C., Diosdado, B., Daly, M.J., Mulder, C.J., Mearin, M.L., Meijer, J.W., Meijer, G.A., van Oort, E., Wapenaar, M.C., Koeleman, B.P., Wijmenga, C. Nat. Genet. (2005) [Pubmed]
  9. Gluten-sensitive enteropathy. Inhibition by cortisol of the effect of gluten protein in vitro. Katz, A.J., Falchuk, Z.M., Strober, W., Shwachman, H. N. Engl. J. Med. (1976) [Pubmed]
  10. Identification of tissue transglutaminase as the autoantigen of celiac disease. Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E.O., Schuppan, D. Nat. Med. (1997) [Pubmed]
  11. Lactulose/mannitol test: an ideal screen for celiac disease. Juby, L.D., Rothwell, J., Axon, A.T. Gastroenterology (1989) [Pubmed]
  12. Gastrointestinal permeability in celiac disease. Smecuol, E., Bai, J.C., Vazquez, H., Kogan, Z., Cabanne, A., Niveloni, S., Pedreira, S., Boerr, L., Mauriño, E., Meddings, J.B. Gastroenterology (1997) [Pubmed]
  13. Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gillett, H.R., Arnott, I.D., McIntyre, M., Campbell, S., Dahele, A., Priest, M., Jackson, R., Ghosh, S. Gastroenterology (2002) [Pubmed]
  14. Reversible insensitivity to androgens in men with untreated gluten enteropathy. Green, J.R., Goble, H.L., Edwards, C.R., Dawson, A.M. Lancet (1977) [Pubmed]
  15. A major role for matrix metalloproteinases in T cell injury in the gut. Pender, S.L., Tickle, S.P., Docherty, A.J., Howie, D., Wathen, N.C., MacDonald, T.T. J. Immunol. (1997) [Pubmed]
  16. Proteomics identification of acyl-acceptor and acyl-donor substrates for transglutaminase in a human intestinal epithelial cell line. Implications for celiac disease. Orrù, S., Caputo, I., D'Amato, A., Ruoppolo, M., Esposito, C. J. Biol. Chem. (2003) [Pubmed]
  17. Factor V deficiency and its reversal with gluten restriction. In a patient with celiac disease. Shanahan, F., Aburajab, A., Goodacre, R., Blajchman, M.A. Arch. Intern. Med. (1983) [Pubmed]
  18. Gluten-sensitive enteropathy and systemic lupus erythematosus. Rustgi, A.K., Peppercorn, M.A. Arch. Intern. Med. (1988) [Pubmed]
  19. Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation. Kumar, R., Eastwood, A.L., Brown, M.L., Laurie, G.W. J. Mol. Biol. (2002) [Pubmed]
  20. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Hüe, S., Mention, J.J., Monteiro, R.C., Zhang, S., Cellier, C., Schmitz, J., Verkarre, V., Fodil, N., Bahram, S., Cerf-Bensussan, N., Caillat-Zucman, S. Immunity (2004) [Pubmed]
  21. TNF-alpha production by intraepithelial T cells in celiac disease. Feighery, C., O'Keefe, J. Gastroenterology (2003) [Pubmed]
  22. Deposition of eosinophil granule major basic protein in eosinophilic gastroenteritis and celiac disease. Talley, N.J., Kephart, G.M., McGovern, T.W., Carpenter, H.A., Gleich, G.J. Gastroenterology (1992) [Pubmed]
  23. Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease. Crenn, P., Vahedi, K., Lavergne-Slove, A., Cynober, L., Matuchansky, C., Messing, B. Gastroenterology (2003) [Pubmed]
  24. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Meresse, B., Chen, Z., Ciszewski, C., Tretiakova, M., Bhagat, G., Krausz, T.N., Raulet, D.H., Lanier, L.L., Groh, V., Spies, T., Ebert, E.C., Green, P.H., Jabri, B. Immunity (2004) [Pubmed]
  25. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. Sollid, L.M., Markussen, G., Ek, J., Gjerde, H., Vartdal, F., Thorsby, E. J. Exp. Med. (1989) [Pubmed]
  26. Immunoglobulin allotype markers in gluten-sensitive enteropathy. Kagnoff, M.F., Weiss, J.B., Brown, R.J., Lee, T., Schanfield, M.S. Lancet (1983) [Pubmed]
  27. Targeting of gliadin peptides, CD8, alpha/beta-TCR, and gamma/delta-TCR to Golgi complexes and vacuoles within celiac disease enterocytes. Zimmer, K.P., Naim, H., Weber, P., Ellis, H.J., Ciclitira, P.J. FASEB J. (1998) [Pubmed]
  28. The role of defective mismatch repair in small bowel adenocarcinoma in celiac disease. Potter, D.D., Murray, J.A., Donohue, J.H., Burgart, L.J., Nagorney, D.M., van Heerden, J.A., Plevak, M.F., Zinsmeister, A.R., Thibodeau, S.N. Cancer Res. (2004) [Pubmed]
  29. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K.L., Korponay-Szabó, I.R., Sarnesto, A., Savilahti, E., Collin, P., Mäki, M. Gastroenterology (1998) [Pubmed]
  30. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Hill, I.D. Gastroenterology (2005) [Pubmed]
  31. Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease. Lavö, B., Knutson, L., Lööf, L., Odlind, B., Venge, P., Hällgren, R. Am. J. Med. (1989) [Pubmed]
  32. Decreased intestinal CYP3A in celiac disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism. Lang, C.C., Brown, R.M., Kinirons, M.T., Deathridge, M.A., Guengerich, F.P., Kelleher, D., O'Briain, D.S., Ghishan, F.K., Wood, A.J. Clin. Pharmacol. Ther. (1996) [Pubmed]
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