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Chemical Compound Review

histidinol     2-amino-3-(3H-imidazol-4- yl)propan-1-ol

Synonyms: L-histidinol, CCRIS 555, SureCN65204, AG-K-70317, SureCN6546332, ...
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Disease relevance of histidinol

  • These experiments demonstrated that L-histidinol not only protected the marrow cell population from both ara-C and FUra, but also increased significantly the toxicities of these agents for the intrafemoral tumor cells [1].
  • The effects of L-histidinol, a structural analog of the essential amino acid L-histidine, on the proliferative responses and anticancer drug vulnerability of cultured spleen cells from male C57BL/6J mice exposed to optimal mitogenic doses of concanavalin A (Con A) or E. coli lipopolysaccharide (LPS) were investigated [2].
  • Simultaneously, the inclusion of L-histidinol provided a statistically significant increase in the capacity of these two anticancer drugs to eradicate intraperitoneal mastocytoma cells [3].
  • In contrast, both L1210 leukemia cells and colon 26 adenocarcinoma cells were more efficiently killed by combinations of L-histidinol and cisplatin [4].
  • However, in contrast to results reported in the L1210 leukemic system, L-histidinol also reduced the cytotoxic activity of FUra against CD8F1 breast tumors [5].

High impact information on histidinol

  • Five of seven histidinol-resistant clones and three of three G418-resistant clones generated germ-line chimeras [6].
  • Selection in L-histidinol or G418 produced clones in which the coding sequences for histidinol-dehydrogenase or neomycin-phosphotransferase were fused to sequences in or near the 5' exons of expressed genes, including one in the developmentally regulated REX-1 gene [6].
  • We showed previously that the transcript from an actin-HIS4 gene fusion containing the mutation TACTAAC to TACTACC (designated C259) is spliced inefficiently, thereby preventing growth on the histidine precursor histidinol [7].
  • By selecting for growth on histidinol, we have identified a mutant in which the splicing of the C259 transcript is increased fourfold; splicing of other mutated introns is not significantly improved [7].
  • Antagonism of the intracellular action of histamine at intracellular histamine receptors by DPPE or histidinol may result in differential perturbations of growth/eicosanoid metabolism in normal and malignant cells, thus forming the basis of a new approach to chemotherapy [8].

Chemical compound and disease context of histidinol


Biological context of histidinol


Anatomical context of histidinol


Associations of histidinol with other chemical compounds


Gene context of histidinol

  • With the CYC1 fragment cloned in its wild-type (forward) orientation within the actin intron, transformants cannot grow on histidinol, whereas cells transformed with the vector carrying the reverse orientation of this fragment are able to grow well [22].
  • Histidine limitation in the presence of histidinol induced a twofold increase in the phosphorylation of eIF2alpha and a concomitant reduction in eIF2B activity in perfused livers from wild-type mice, but no changes in livers from Gcn2(-/-) mice [23].
  • Nucleotide and amino acid polymorphism in the gene for L-histidinol dehydrogenase of Escherichia coli K12 [24].
  • Two classes of mutations were obtained: (i) those that altered the coding region of HOL1, conferring the ability to take up histidinol; and (ii) cis-acting mutations (selected in a mutant HOL1-1 background) that increased expression of the Hol1 protein [25].
  • The crystal structures of HisRS from two organisms and their complexes with histidine, histidyl-adenylate and histidinol with ATP have been solved [26].

Analytical, diagnostic and therapeutic context of histidinol

  • Southern blot analysis of wild-type and histidinol-resistant cells with this cDNA showed that the histidyl-tRNA synthetase DNA bands were amplified in the resistant cells [17].
  • Immunoprecipitation of [35S]methionine-labeled cell lysates with antibodies to histidyl-tRNA synthetase showed increased synthesis of the enzyme in histidinol-resistant cells [17].
  • The transgenic embryonic fibroblasts survive under a wide range of histidinol-containing growth conditions and support growth of ES cell cultures [27].
  • Gel filtration analysis indicate the aromatic and histidinol phosphate aminotransferases have molecular weights of 63,500 and 33,000, respectively [28].
  • Analysis of individual protein bands by SDS-PAGE showed that at least 17 bands became less prominent, while 13 polypeptides became more prominent, during exposure to histidinol [29].


  1. Histidinol-mediated enhancement of the specificity of two anticancer drugs in mice bearing leukemic bone marrow disease. Warrington, R.C., Fang, W.D. J. Natl. Cancer Inst. (1985) [Pubmed]
  2. L-histidinol protection against cytotoxic action of cytosine arabinoside and 5-fluorouracil in cultured mouse spleen cells. Warrington, R.C., Fang, W.D. J. Natl. Cancer Inst. (1982) [Pubmed]
  3. Effects of L-histidinol on the susceptibility of P815 mastocytoma cells to selected anticancer drugs in vitro and in DBA/2J mice. Warrington, R.C., Cheng, I., Fang, W.D. J. Natl. Cancer Inst. (1987) [Pubmed]
  4. Infused L-histidinol and cisplatin: schedule, specificity, and proliferation dependence. Edelstein, M.B. J. Natl. Cancer Inst. (1989) [Pubmed]
  5. Failure of L-histidinol to improve the therapeutic efficiency of 5-fluorouracil against murine breast tumors. Stolfi, R.L., Sawyer, R.C., Martin, D.S. Cancer Res. (1987) [Pubmed]
  6. Selective disruption of genes expressed in totipotent embryonal stem cells. von Melchner, H., DeGregori, J.V., Rayburn, H., Reddy, S., Friedel, C., Ruley, H.E. Genes Dev. (1992) [Pubmed]
  7. A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Couto, J.R., Tamm, J., Parker, R., Guthrie, C. Genes Dev. (1987) [Pubmed]
  8. Increased therapeutic index of antineoplastic drugs in combination with intracellular histamine antagonists. Brandes, L.J., LaBella, F.S., Warrington, R.C. J. Natl. Cancer Inst. (1991) [Pubmed]
  9. Histidinol-mediated improvement in the specificity of 1-beta-D-arabinofuranosylcytosine and 5-fluorouracil in L 1210 leukemia-bearing mice. Warrington, R.C., Muzyka, T.G., Fang, W.D. Cancer Res. (1984) [Pubmed]
  10. Structural Snapshots of Escherichia coli Histidinol Phosphate Phosphatase along the Reaction Pathway. Rangarajan, E.S., Proteau, A., Wagner, J., Hung, M.N., Matte, A., Cygler, M. J. Biol. Chem. (2006) [Pubmed]
  11. Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. Sivaraman, J., Li, Y., Larocque, R., Schrag, J.D., Cygler, M., Matte, A. J. Mol. Biol. (2001) [Pubmed]
  12. Identification of cellular promoters by using a retrovirus promoter trap. von Melchner, H., Ruley, H.E. J. Virol. (1989) [Pubmed]
  13. Reversal of the multidrug-resistant phenotype of Chinese hamster ovary cells by L-histidinol. Warrington, R.C., Fang, W.D. J. Natl. Cancer Inst. (1989) [Pubmed]
  14. Structural and functional conservation of histidinol dehydrogenase between plants and microbes. Nagai, A., Ward, E., Beck, J., Tada, S., Chang, J.Y., Scheidegger, A., Ryals, J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  15. Isolation of cellular promoters by using a retrovirus promoter trap. von Melchner, H., Reddy, S., Ruley, H.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  16. Selective killing of oncogenic human cells cocultivated with normal human fibroblasts. Warrington, R.C. J. Natl. Cancer Inst. (1978) [Pubmed]
  17. Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells. Tsui, F.W., Andrulis, I.L., Murialdo, H., Siminovitch, L. Mol. Cell. Biol. (1985) [Pubmed]
  18. The product of the his4 gene cluster in Saccharomyces cerevisiae. A trifunctional polypeptide. Keesey, J.K., Bigelis, R., Fink, G.R. J. Biol. Chem. (1979) [Pubmed]
  19. L-histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential. Stockschlaeder, M.A., Storb, R., Osborne, W.R., Miller, A.D. Hum. Gene Ther. (1991) [Pubmed]
  20. Mechanism of Salmonella typhimurium histidinol dehydrogenase: kinetic isotope effects and pH profiles. Grubmeyer, C., Teng, H. Biochemistry (1999) [Pubmed]
  21. A cysteine residue (cysteine-116) in the histidinol binding site of histidinol dehydrogenase. Grubmeyer, C.T., Gray, W.R. Biochemistry (1986) [Pubmed]
  22. Orientation-dependent function of a short CYC1 DNA fragment in directing mRNA 3' end formation in yeast. Ruohola, H., Baker, S.M., Parker, R., Platt, T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  23. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Zhang, P., McGrath, B.C., Reinert, J., Olsen, D.S., Lei, L., Gill, S., Wek, S.A., Vattem, K.M., Wek, R.C., Kimball, S.R., Jefferson, L.S., Cavener, D.R. Mol. Cell. Biol. (2002) [Pubmed]
  24. Nucleotide and amino acid polymorphism in the gene for L-histidinol dehydrogenase of Escherichia coli K12. Jovanović, G., Kostić, T., Savić, D.J. Nucleic Acids Res. (1990) [Pubmed]
  25. Amino acid substitutions in membrane-spanning domains of Hol1, a member of the major facilitator superfamily of transporters, confer nonselective cation uptake in Saccharomyces cerevisiae. Wright, M.B., Howell, E.A., Gaber, R.F. J. Bacteriol. (1996) [Pubmed]
  26. Histidyl-tRNA synthetase. Freist, W., Verhey, J.F., Rühlmann, A., Gauss, D.H., Arnez, J.G. Biol. Chem. (1999) [Pubmed]
  27. Transgenic mice for the establishment of histidinol-resistant embryonic fibroblast feeder layers. Tucker, R.M., Burke, D.T. FASEB J. (1996) [Pubmed]
  28. Purification and properties of two aromatic aminotransferases in Bacillus subtilis. Weigent, D.A., Nester, E.W. J. Biol. Chem. (1976) [Pubmed]
  29. 'Stress-proteins' are induced in Tetrahymena pyriformis by histidinol but not in mammalian (L-929) cells. Ron, A., Wheatley, D.N. Exp. Cell Res. (1984) [Pubmed]
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