Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN188787 [(2R,3S,4R,5R)-5-amino-3,4- dihydroxy...

Synonyms: CHEBI:37737, HMDB01128, AC1L98A6, C03090, GRF, ...

Kamal, M.A. et al., Jayaram, H.N. et al.

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Disease relevance of 5-O-PHOSPHONO-BETA-D-RIBOFURANOSYLAMINE

L-Glutamate synthetase of Escherichia coli is only modestly inhibited and 5-phosphoribosylamine synthesis in fetal rat liver is comparatively refractory to inhibition [1].

High impact information on 5-O-PHOSPHONO-BETA-D-RIBOFURANOSYLAMINE

Amido phosphoribosyltransferase (APRT) catalyzes the first step of the de novo biosynthesis of purine nucleotides, the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosylamine (PRA) [2].

References

L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine. Jayaram, H.N., Cooney, D.A., Ryan, J.A., Neil, G., Dion, R.L., Bono, V.H. Cancer chemotherapy reports. Part 1. (1975) [Pubmed]
Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates. Kamal, M.A., Christopherson, R.I. Int. J. Biochem. Cell Biol. (2004) [Pubmed]

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