Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L993W [(2R,5R)-5-(2- formamidoethanoylamino)- 3,4...

Synonyms:

Grindey, G.B. et al., Nagy, P.L. et al., Divekar, A.Y. et al.

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Disease relevance of C04376

The metabolic basis of this synergism was approached in a study of the incorporation of [14C]glycine into 5'-phosphoribosyl-N-formylglycinamide in Sarcoma 180 cells [1].

High impact information on C04376

Mutations in either of two pairs of genes are required to block synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) from GAR: purN purT (purT encodes an alternative formate-dependent GAR transformylase) or purN purU [2].

Chemical compound and disease context of C04376

Inhibition of the biosynthesis of 5'-phosphoribosyl-N-formylglycinamide in sarcoma 180 cells by homofolate [3].

References

Potentiation by guanine nucleosides of the growth-inhibitory effects of adenosine analogs on L1210 and sarcoma 180 cells in culture. Grindey, G.B., Lowe, J.K., Divekar, A.Y., Hakala, M.T. Cancer Res. (1976) [Pubmed]
purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis. Nagy, P.L., McCorkle, G.M., Zalkin, H. J. Bacteriol. (1993) [Pubmed]
Inhibition of the biosynthesis of 5'-phosphoribosyl-N-formylglycinamide in sarcoma 180 cells by homofolate. Divekar, A.Y., Hakala, M.T. Mol. Pharmacol. (1975) [Pubmed]

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