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Chemical Compound Review:

SureCN12497060 2-amino-3-[4-(3-methylbut-2- enyl)-1H-indol...

Synonyms: AC1L9A5J, C06067, 5017-33-4, Dimethylallyltryptophan, 4-Dimethylallyltryptophan, ...

Li, S.M. et al., Unsöld, I.A. et al., Rigbers, O. et al.

Uns??ld, Li,

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High impact information on C06067

FgaPT2 converts L-tryptophan to dimethylallyltryptophan and thereby catalyzes the first step of ergot alkaloid biosynthesis, whilst FgaPT1 catalyzes the last step of the fumigaclavine C biosynthesis, i. e., the prenylation of fumigaclavine A at C-2 position of the indole nucleus [1].
A putative dimethylallyltryptophan synthase gene, fgaPT2, was identified in the genome sequence of Aspergillus fumigatus. fgaPT2 was cloned and overexpressed in Saccharomyces cerevisiae [2].

Associations of C06067 with other chemical compounds

4-Dimethylallyltryptophan derivatives with modification at the indole ring were also accepted by FgaMT as substrates [3].

References

Post-genome research on the biosynthesis of ergot alkaloids. Li, S.M., Uns??ld, I.A. Planta Med. (2006) [Pubmed]
Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Unsöld, I.A., Li, S.M. Microbiology (Reading, Engl.) (2005) [Pubmed]
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase. Rigbers, O., Li, S.M. J. Biol. Chem. (2008) [Pubmed]

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