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Chemical Compound Review:

ACMC-20n5wk 6-chlorobenzene-1,2,4-triol

Synonyms: AC1L9ABM, CTK0E8586, C06328, 6-CHQ, 150097-90-8, ...

Zaborina, O. et al., Xun, L. et al.

Xun, Webster,

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Disease relevance of C06328

Ralstonia eutropha JMP134 2,4,6-trichlorophenol (2,4,6-TCP) 4-monooxygenase catalyzes sequential dechlorinations of 2,4,6-TCP to 6-chlorohydroxyquinol [1].
Purification and characterization of 6-chlorohydroxyquinol 1,2-dioxygenase from Streptomyces rochei 303: comparison with an analogous enzyme from Azotobacter sp. strain GP1 [2].
The enzyme which cleaves the benzene ring of 6-chlorohydroxyquinol was purified to apparent homogeneity from an extract of 2,4,6-trichlorophenol-grown cells of Streptomyces rochei 303 [2].

High impact information on C06328

The NH2-terminal amino acid sequences of 6-chlorohydroxyquinol 1,2-dioxygenase from S. rochei 303 and from Azotobacter sp. strain GP1 showed a high degree of similarity [2].
In contrast to 6-chlorohydroxyquinol 1,2-dioxygenase from Azotobacter sp. strain GP1, the S. rochei enzyme had a distinct preference for 6-chlorohydroxyquinol over hydroxyquinol (kcat/Km = 1.2 and 0.57 s-1.microM-1, respectively) [2].

References

A monooxygenase catalyzes sequential dechlorinations of 2,4,6-trichlorophenol by oxidative and hydrolytic reactions. Xun, L., Webster, C.M. J. Biol. Chem. (2004) [Pubmed]
Purification and characterization of 6-chlorohydroxyquinol 1,2-dioxygenase from Streptomyces rochei 303: comparison with an analogous enzyme from Azotobacter sp. strain GP1. Zaborina, O., Latus, M., Eberspächer, J., Golovleva, L.A., Lingens, F. J. Bacteriol. (1995) [Pubmed]

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