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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Ralstonia

 
 
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Disease relevance of Ralstonia

 

High impact information on Ralstonia

  • We have established that the membrane-bound hydrogenase from the beta-proteobacterium Ralstonia eutropha H16, when adsorbed at a graphite electrode, exhibits rapid electrocatalytic oxidation of hydrogen that is completely unaffected by carbon monoxide [at 0.9 bar (1 bar = 100 kPa), a 9-fold excess] and is inhibited only partially by oxygen [6].
  • These assays showed that NorR, a homolog of NO-responsive transcription factors in Ralstonia eutrophus, and Fur, the global repressor of ferric ion uptake, are major regulators of the response to reactive nitrogen species [7].
  • Controlling the regiospecific oxidation of aromatics via active site engineering of toluene para-monooxygenase of Ralstonia pickettii PKO1 [8].
  • The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan [9].
  • Ralstonia eutropha JMP134 2,4,6-trichlorophenol (2,4,6-TCP) 4-monooxygenase catalyzes sequential dechlorinations of 2,4,6-TCP to 6-chlorohydroxyquinol [10].
 

Chemical compound and disease context of Ralstonia

  • Identification of 3-hydroxypalmitic acid methyl ester as a novel autoregulator controlling virulence in Ralstonia solanacearum [11].
  • Two novel proteins, PopB, which has functional nuclear localization signals, and PopC, which has a large leucine-rich repeat domain, are secreted through the hrp-secretion apparatus of Ralstonia solanacearum [12].
  • In contrast, the membrane-bound [NiFe]-hydrogenase from the aerobe, Ralstonia eutropha, reacts reversibly with O2 even during turnover and continues to catalyze H2 oxidation in the presence of O2 [13].
  • OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii [14].
  • Mobilization of poly(3-hydroxybutyrate) in Ralstonia eutropha [15].
 

Biological context of Ralstonia

 

Anatomical context of Ralstonia

 

Gene context of Ralstonia

  • QRP1, the locus showing the strongest effect, was found to correspond to the ERECTA (ER) gene that encodes a receptor-like-kinase (RLK), which has been previously implicated in plant development, and resistance to the bacterium Ralstonia solanacearum [24].
  • The tfdR gene product can successfully take over the role of the insertion element-inactivated TfdT protein as a transcriptional activator of the tfdCDEF gene cluster, which encodes chlorocatechol degradation in Ralstonia eutropha JMP134(pJP4) [25].
  • The gene associated with the loss of growth promotion in H41 was shown to exhibit 65% identity at the amino acid level to the nadC gene encoding quinolinate phosphoribosyltransferase (QAPRTase) in Ralstonia solanacearum [26].
  • Analysis of 4-phosphopantetheinylation of polyhydroxybutyrate synthase from Ralstonia eutropha: generation of beta-alanine auxotrophic Tn5 mutants and cloning of the panD gene region [27].
  • ZAT1p functioned as an uptake system for 65Zn2+ in two strains of the Gram-negative bacterium Ralstonia metallidurans, which were different in their content of zinc-efflux systems [28].
 

Analytical, diagnostic and therapeutic context of Ralstonia

  • Structural and oxidation-state changes at its nonstandard Ni-Fe site during activation of the NAD-reducing hydrogenase from Ralstonia eutropha detected by X-ray absorption, EPR, and FTIR spectroscopy [29].
  • Sequence analysis of several cDNAs encoding the phasin protein of Ralstonia eutropha indicated that the carboxyl terminus of the resulting derived protein sequence is different from that reported previously [30].
  • We designed a real-time PCR assay able to recognize dioxygenase large-subunit gene sequences with more than 90% similarity to the Ralstonia sp. strain U2 nagAc gene (nagAc-like gene sequences) in order to study the importance of organisms carrying these genes in the biodegradation of naphthalene [31].
  • Protein engineering of the archetypal nitroarene dioxygenase of Ralstonia sp. strain U2 for activity on aminonitrotoluenes and dinitrotoluenes through alpha-subunit residues leucine 225, phenylalanine 350, and glycine 407 [32].
  • A dichloromethane (DCM)-degrading bacterium, Ralstonia metallidurans PD11 NBRC 101272, was immobilized in a polyvinyl alcohol (PVA) gel to use in a bioreactor for DCM treatment [33].

References

  1. Quorum-sensing in Gram-negative bacteria. Whitehead, N.A., Barnard, A.M., Slater, H., Simpson, N.J., Salmond, G.P. FEMS Microbiol. Rev. (2001) [Pubmed]
  2. A new Ralstonia solanacearum high-affinity mannose-binding lectin RS-IIL structurally resembling the Pseudomonas aeruginosa fucose-specific lectin PA-IIL. Sudakevitz, D., Kostlánová, N., Blatman-Jan, G., Mitchell, E.P., Lerrer, B., Wimmerová, M., Katcoff, D.J., Imberty, A., Gilboa-Garber, N. Mol. Microbiol. (2004) [Pubmed]
  3. Glyceraldehyde-3-phosphate dehydrogenase gene diversity in eubacteria and eukaryotes: evidence for intra- and inter-kingdom gene transfer. Figge, R.M., Schubert, M., Brinkmann, H., Cerff, R. Mol. Biol. Evol. (1999) [Pubmed]
  4. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Jia, Y., Yuan, W., Wodzinska, J., Park, C., Sinskey, A.J., Stubbe, J. Biochemistry (2001) [Pubmed]
  5. Transformation of chlorinated benzenes and toluenes by Ralstonia sp. strain PS12 tecA (tetrachlorobenzene dioxygenase) and tecB (chlorobenzene dihydrodiol dehydrogenase) gene products. Pollmann, K., Beil, S., Pieper, D.H. Appl. Environ. Microbiol. (2001) [Pubmed]
  6. Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels. Vincent, K.A., Cracknell, J.A., Lenz, O., Zebger, I., Friedrich, B., Armstrong, F.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species. Mukhopadhyay, P., Zheng, M., Bedzyk, L.A., LaRossa, R.A., Storz, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Controlling the regiospecific oxidation of aromatics via active site engineering of toluene para-monooxygenase of Ralstonia pickettii PKO1. Fishman, A., Tao, Y., Rui, L., Wood, T.K. J. Biol. Chem. (2005) [Pubmed]
  9. The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan. Kostlánová, N., Mitchell, E.P., Lortat-Jacob, H., Oscarson, S., Lahmann, M., Gilboa-Garber, N., Chambat, G., Wimmerová, M., Imberty, A. J. Biol. Chem. (2005) [Pubmed]
  10. A monooxygenase catalyzes sequential dechlorinations of 2,4,6-trichlorophenol by oxidative and hydrolytic reactions. Xun, L., Webster, C.M. J. Biol. Chem. (2004) [Pubmed]
  11. Identification of 3-hydroxypalmitic acid methyl ester as a novel autoregulator controlling virulence in Ralstonia solanacearum. Flavier, A.B., Clough, S.J., Schell, M.A., Denny, T.P. Mol. Microbiol. (1997) [Pubmed]
  12. Two novel proteins, PopB, which has functional nuclear localization signals, and PopC, which has a large leucine-rich repeat domain, are secreted through the hrp-secretion apparatus of Ralstonia solanacearum. Guéneron, M., Timmers, A.C., Boucher, C., Arlat, M. Mol. Microbiol. (2000) [Pubmed]
  13. Electrochemical definitions of O2 sensitivity and oxidative inactivation in hydrogenases. Vincent, K.A., Parkin, A., Lenz, O., Albracht, S.P., Fontecilla-Camps, J.C., Cammack, R., Friedrich, B., Armstrong, F.A. J. Am. Chem. Soc. (2005) [Pubmed]
  14. OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii. Girlich, D., Naas, T., Nordmann, P. Antimicrob. Agents Chemother. (2004) [Pubmed]
  15. Mobilization of poly(3-hydroxybutyrate) in Ralstonia eutropha. Handrick, R., Reinhardt, S., Jendrossek, D. J. Bacteriol. (2000) [Pubmed]
  16. Genetic dissection of Ralstonia solanacearum hrp gene cluster reveals that the HrpV and HrpX proteins are required for Hrp pilus assembly. Van Gijsegem, F., Vasse, J., De Rycke, R., Castello, P., Boucher, C. Mol. Microbiol. (2002) [Pubmed]
  17. Purification and properties of an intracellular 3-hydroxybutyrate-oligomer hydrolase (PhaZ2) in Ralstonia eutropha H16 and its identification as a novel intracellular poly(3-hydroxybutyrate) depolymerase. Kobayashi, T., Shiraki, M., Abe, T., Sugiyama, A., Saito, T. J. Bacteriol. (2003) [Pubmed]
  18. The naphthalene catabolic (nag) genes of Ralstonia sp. strain U2 are an operon that is regulated by NagR, a LysR-type transcriptional regulator. Jones, R.M., Britt-Compton, B., Williams, P.A. J. Bacteriol. (2003) [Pubmed]
  19. Chemotaxis of Ralstonia eutropha JMP134(pJP4) to the herbicide 2,4-dichlorophenoxyacetate. Hawkins, A.C., Harwood, C.S. Appl. Environ. Microbiol. (2002) [Pubmed]
  20. Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2. Gabriel, D.W., Allen, C., Schell, M., Denny, T.P., Greenberg, J.T., Duan, Y.P., Flores-Cruz, Z., Huang, Q., Clifford, J.M., Presting, G., González, E.T., Reddy, J., Elphinstone, J., Swanson, J., Yao, J., Mulholland, V., Liu, L., Farmerie, W., Patnaikuni, M., Balogh, B., Norman, D., Alvarez, A., Castillo, J.A., Jones, J., Saddler, G., Walunas, T., Zhukov, A., Mikhailova, N. Mol. Plant Microbe Interact. (2006) [Pubmed]
  21. Infection by Ralstonia species in cystic fibrosis patients: identification of R. pickettii and R. mannitolilytica by polymerase chain reaction. Coenye, T., Vandamme, P., LiPuma, J.J. Emerging Infect. Dis. (2002) [Pubmed]
  22. Cesium desorption from illite as affected by exudates from rhizosphere bacteria. Wendling, L.A., Harsh, J.B., Ward, T.E., Palmer, C.D., Hamilton, M.A., Boyle, J.S., Flury, M. Environ. Sci. Technol. (2005) [Pubmed]
  23. Effects of 2,2',5,5'-tetrachlorobiphenyl and biphenyl on cell membranes of Ralstonia eutropha H850. Kim, I.S., Lee, H., Trevors, J.T. FEMS Microbiol. Lett. (2001) [Pubmed]
  24. ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resistance to the necrotrophic fungus Plectosphaerella cucumerina. Llorente, F., Alonso-Blanco, C., Sánchez-Rodriguez, C., Jorda, L., Molina, A. Plant J. (2005) [Pubmed]
  25. The tfdR gene product can successfully take over the role of the insertion element-inactivated TfdT protein as a transcriptional activator of the tfdCDEF gene cluster, which encodes chlorocatechol degradation in Ralstonia eutropha JMP134(pJP4). Leveau, J.H., van der Meer, J.R. J. Bacteriol. (1996) [Pubmed]
  26. Involvement of quinolinate phosphoribosyl transferase in promotion of potato growth by a Burkholderia strain. Wang, K., Conn, K., Lazarovits, G. Appl. Environ. Microbiol. (2006) [Pubmed]
  27. Analysis of 4-phosphopantetheinylation of polyhydroxybutyrate synthase from Ralstonia eutropha: generation of beta-alanine auxotrophic Tn5 mutants and cloning of the panD gene region. Hoppensack, A., Rehm, B.H., Steinbüchel, A. J. Bacteriol. (1999) [Pubmed]
  28. Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomes. Bloss, T., Clemens, S., Nies, D.H. Planta (2002) [Pubmed]
  29. Structural and oxidation-state changes at its nonstandard Ni-Fe site during activation of the NAD-reducing hydrogenase from Ralstonia eutropha detected by X-ray absorption, EPR, and FTIR spectroscopy. Burgdorf, T., Löscher, S., Liebisch, P., Van der Linden, E., Galander, M., Lendzian, F., Meyer-Klaucke, W., Albracht, S.P., Friedrich, B., Dau, H., Haumann, M. J. Am. Chem. Soc. (2005) [Pubmed]
  30. Re-evaluation of the primary structure of Ralstonia eutropha phasin and implications for polyhydroxyalkanoic acid granule binding. Hanley, S.Z., Pappin, D.J., Rahman, D., White, A.J., Elborough, K.M., Slabas, A.R. FEBS Lett. (1999) [Pubmed]
  31. Abundance of dioxygenase genes similar to Ralstonia sp. strain U2 nagAc is correlated with naphthalene concentrations in coal tar-contaminated freshwater sediments. Dionisi, H.M., Chewning, C.S., Morgan, K.H., Menn, F.M., Easter, J.P., Sayler, G.S. Appl. Environ. Microbiol. (2004) [Pubmed]
  32. Protein engineering of the archetypal nitroarene dioxygenase of Ralstonia sp. strain U2 for activity on aminonitrotoluenes and dinitrotoluenes through alpha-subunit residues leucine 225, phenylalanine 350, and glycine 407. Keenan, B.G., Leungsakul, T., Smets, B.F., Mori, M.A., Henderson, D.E., Wood, T.K. J. Bacteriol. (2005) [Pubmed]
  33. Biodegradation of dichloromethane by the polyvinyl alcohol-immobilized methylotrophic bacterium Ralstonia metallidurans PD11. Miyake-Nakayama, C., Ikatsu, H., Kashihara, M., Tanaka, M., Arita, M., Miyoshi, S., Shinoda, S. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
 
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