Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

HMDB01295 [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: AC1L9AUR, 3S2HPhy-CoA, 3S2HPhy-Coenzyme A, 2-Hydroxyphytanoyl-CoA, (3S)-2-hydroxyphytanoyl-CoA, ...

Verhoeven, N.M. et al., Jansen, G.A. et al., Verhoeven, N.M. et al.

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High impact information on C07343

Phytanic acid alpha-oxidation: decarboxylation of 2-hydroxyphytanoyl-CoA to pristanic acid in human liver [1].
Recent studies have shown that phytanic acid first undergoes activation to its coenzyme A ester, followed by hydroxylation to 2-hydroxyphytanoyl-CoA [2].
We have studied the second step in the alpha-oxidation pathway, which involves conversion of 2-hydroxyphytanoyl-CoA to pristanal catalysed by 2-hydroxyphytanoyl-CoA lyase [3].

Associations of C07343 with other chemical compounds

Resolution of the phytanic acid alpha-oxidation pathway: identification of pristanal as product of the decarboxylation of 2-hydroxyphytanoyl-CoA [2].

References

Phytanic acid alpha-oxidation: decarboxylation of 2-hydroxyphytanoyl-CoA to pristanic acid in human liver. Verhoeven, N.M., Wanders, R.J., Schor, D.S., Jansen, G.A., Jakobs, C. J. Lipid Res. (1997) [Pubmed]
Resolution of the phytanic acid alpha-oxidation pathway: identification of pristanal as product of the decarboxylation of 2-hydroxyphytanoyl-CoA. Verhoeven, N.M., Schor, D.S., ten Brink, H.J., Wanders, R.J., Jakobs, C. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
Phytanic acid alpha-oxidation: identification of 2-hydroxyphytanoyl-CoA lyase in rat liver and its localisation in peroxisomes. Jansen, G.A., Verhoeven, N.M., Denis, S., Romeijn, G., Jakobs, C., ten Brink, H.J., Wanders, R.J. Biochim. Biophys. Acta (1999) [Pubmed]

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