Disease relevance of Sophoranone

• Sophoranone inhibited cell growth and induced apoptosis in various lines of cells from human solid tumors, with 50% inhibition of growth of human stomach cancer MKN7 cells at 1.2 +/- 0.3 microM [1].

High impact information on Sophoranone

• Inhibitors of complexes III and IV, but not complexes I and II, of the mitochondrial respiratory chain prevented the release of cytochrome c from isolated mitochondria by sophoranone, as well as the induction of apoptosis in U937 cells in response to sophoranone [1].
• Our results indicate that sophoranone might be a unique apoptosis-inducing anticancer agent that targets mitochondria [1].
• At the early stages of treatment of U937 cells with sophoranone, reactive oxygen species were formed, mitochondrial permeability pores were opened and cytochrome c was released from mitochondria [1].

Biological context of Sophoranone

• Chen. We purified the compound that induced apoptosis in human leukemia cells and identified it as sophoranone [1].

Anatomical context of Sophoranone

• Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores [1].

Gene context of Sophoranone

• Cytochrome c was also released upon treatment of isolated mitochondria with sophoranone [1].

References