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Chemical Compound Review

Biflorin     5,7-dihydroxy-2-methyl-6- [(2R,3R,4R,5S,6R)...

Synonyms: CHEMBL463312, HMDB02336, AC1L9C08, C08996, 89701-85-9
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Disease relevance of C08996

  • Biflorin lacked activity on mouse erythrocytes as well as on the development of sea urchin eggs, but strongly inhibited the growth of all five tested tumor cell lines, especially the skin, breast and colon cancer cells with IC50 of 0.40, 0.43 and 0.88 micro/ml for B16, MCF-7 and HCT-8, respectively [1].

High impact information on C08996

  • The fractionation of Eugenia caryophyllata (Myrtaceae) guided by the syncytia formation inhibition assay led to the isolation of four tannins (eugeniin, casuarictin, 1,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose, and tellimagrandin I), and two chromones (biflorin and isobiflorin) [2].


  1. Bioactivity of biflorin, a typical o-naphthoquinone isolated from Capraria biflora L. Vasconcellos, M.C., Montenegro, R.C., Militão, G.C., Fonseca, A.M., Pessoa, O.D., Lemos, T.L., Pessoa, C., Moraes, M.O., Costa-Lotufo, L.V. Z. Naturforsch., C, J. Biosci. (2005) [Pubmed]
  2. Isolation of virus-cell fusion inhibitory components from Eugenia caryophyllata. Kim, H.J., Lee, J.S., Woo, E.R., Kim, M.K., Yang, B.S., Yu, Y.G., Park, H., Lee, Y.S. Planta Med. (2001) [Pubmed]
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