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Chemical Compound Review:

AG-G-66470 (4R)-4-hydroxy-6- (hydroxymethyl)-1-methyl...

Synonyms: CTK2F6687, 6887-34-9

Xia, Q. et al., Niwa, H. et al., Lin, G. et al., Mroczek, T. et al., Lin, G. et al.

Mroczek, Ndjoko, Głowniak, Hostettmann,

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High impact information on Otonecine

This is the first report that DHP-derived DNA adducts are formed from the metabolic activation of otonecine type PA and that these DHP-derived DNA adducts are potential biomarkers of PA exposure and PA-induced tumorigenicity [1].
Different PAs (N-oxides, free bases, otonecine alkaloids) isolated were separated on Waters XTerra C18 column using a gradient elution [2].
The metabolism of the hepatotoxic otonecine-type pyrrolizidine alkaloid (PA), clivorine, was investigated using rat liver microsomes [3].
Separation and determination of macrocyclic pyrrolizidine alkaloids of the otonecine type present in the edible plant Petasites japonicus by reversed-phase high-performance liquid chromatography [4].

Anatomical context of Otonecine

In this study, we report that the metabolism of clivorine, a tumorigenic otonecine type PA, by F344 rat liver microsomes results in DHP formation [1].

Analytical, diagnostic and therapeutic context of Otonecine

Therefore, the male rat and guinea pig should be the suitable animal models for further studies of bioactivation and deactivation of otonecine-type PA, respectively [5].

References

Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. Xia, Q., Chou, M.W., Lin, G., Fu, P.P. Chem. Res. Toxicol. (2004) [Pubmed]
On-line structure characterization of pyrrolizidine alkaloids in Onosma stellulatum and Emilia coccinea by liquid chromatography-ion-trap mass spectrometry. Mroczek, T., Ndjoko, K., Głowniak, K., Hostettmann, K. Journal of chromatography. A. (2004) [Pubmed]
Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid. Lin, G., Cui, Y.Y., Hawes, E.M. Drug Metab. Dispos. (2000) [Pubmed]
Separation and determination of macrocyclic pyrrolizidine alkaloids of the otonecine type present in the edible plant Petasites japonicus by reversed-phase high-performance liquid chromatography. Niwa, H., Ishiwata, H., Yamada, K. J. Chromatogr. (1983) [Pubmed]
Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine. Lin, G., Cui, Y.Y., Liu, X.Q., Wang, Z.T. Chem. Res. Toxicol. (2002) [Pubmed]

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