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Chemical Compound Review

AG-G-66470     (4R)-4-hydroxy-6- (hydroxymethyl)-1-methyl...

Synonyms: CTK2F6687, 6887-34-9
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High impact information on Otonecine

  • This is the first report that DHP-derived DNA adducts are formed from the metabolic activation of otonecine type PA and that these DHP-derived DNA adducts are potential biomarkers of PA exposure and PA-induced tumorigenicity [1].
  • Different PAs (N-oxides, free bases, otonecine alkaloids) isolated were separated on Waters XTerra C18 column using a gradient elution [2].
  • The metabolism of the hepatotoxic otonecine-type pyrrolizidine alkaloid (PA), clivorine, was investigated using rat liver microsomes [3].
  • Separation and determination of macrocyclic pyrrolizidine alkaloids of the otonecine type present in the edible plant Petasites japonicus by reversed-phase high-performance liquid chromatography [4].

Anatomical context of Otonecine


Analytical, diagnostic and therapeutic context of Otonecine


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