Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

SureCN574910 [9-[4-(chloromethyl)phenyl]- 6...

Synonyms: CHEBI:9494, AC1L9EF2, C11622, Tetramethylrosamine

Muñoz-Martínez, F. et al., West, J.A. et al., Gibson, S.L. et al., Gibson, S.L. et al., Tombline, G. et al., et al.

Tombline, Donnelly, Holt, You, Ye, Gannon, Nygren, Detty,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tetramethylrosamine

Drug uptake was determined by measuring accumulation of tetramethylrosamine in multidrug resistant NCI AdrR human adenocarcinoma cells [1].
Structure-activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells [2].

High impact information on Tetramethylrosamine

Moreover, sesquiterpenes inhibited at submicromolar concentrations the P-glycoprotein-mediated transport of [(3)H]colchicine and tetramethylrosamine in plasma membrane from CH(R)B30 cells and P-glycoprotein-enriched proteoliposomes, supporting that P-glycoprotein is their molecular target [3].
Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state [4].
The sulfhydryl-binding fluorochrome BODIPY, which colocalized with tetramethylrosamine, a mitochondrial dye, demonstrated by confocal microscopy that cellular sulfhydryls are highest in the mitochondria, next-highest in cytoplasm, and lowest in the nucleus [5].
Tetramethylrosamine (TMR) is excluded from P-glycoprotein (MDR1)-enriched cell lines, but it stains efficiently MDR1-poor parent lines [6].
Several thio and seleno analogues of tetramethylrosamine (TMR) were prepared [2].

Gene context of Tetramethylrosamine

Tetramethylrosamine and its thio- and seleno- analogues (TMR-O, TMR-S, and TMR-Se, respectively) were examined for their ability to be transported by Pgp into chemo-resistant CR1R12 cells [7].

References

Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells. Lavie, Y., Harel-Orbital, T., Gaffield, W., Liscovitch, M. Anticancer Res. (2001) [Pubmed]
Structure-activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells. Gibson, S.L., Holt, J.J., Ye, M., Donnelly, D.J., Ohulchanskyy, T.Y., You, Y., Detty, M.R. Bioorg. Med. Chem. (2005) [Pubmed]
Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance. Muñoz-Martínez, F., Lu, P., Cortés-Selva, F., Pérez-Victoria, J.M., Jiménez, I.A., Ravelo, A.G., Sharom, F.J., Gamarro, F., Castanys, S. Cancer Res. (2004) [Pubmed]
Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state. Tombline, G., Donnelly, D.J., Holt, J.J., You, Y., Ye, M., Gannon, M.K., Nygren, C.L., Detty, M.R. Biochemistry (2006) [Pubmed]
Heterogeneity of clara cell glutathione. A possible basis for differences in cellular responses to pulmonary cytotoxicants. West, J.A., Chichester, C.H., Buckpitt, A.R., Tyler, N.K., Brennan, P., Helton, C., Plopper, C.G. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1. Carter, A., Dann, E.J., Katz, T., Shechter, Y., Oliven, A., Regev, R., Eytan, E., Rowe, J.M., Eytan, G.D. Br. J. Haematol. (2001) [Pubmed]
Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance. Gibson, S.L., Hilf, R., Donnelly, D.J., Detty, M.R. Bioorg. Med. Chem. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.