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Chemical Compound Review:

CHEMBL259621 (2R)-2-benzylbutanedioic acid

Synonyms: AG-E-56148, SureCN1915564, CHEBI:41241, AC1L9GWU, CTK4E6400, ...

Johansen, J.T. et al., Bullock, T.L. et al., Bolognesi, M.C. et al.

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High impact information on l-benzylsuccinic acid

Structure of the complex of L-benzylsuccinate with wheat serine carboxypeptidase II at 2.0-A resolution [1].
L-Benzylsuccinate occupies a narrow slot in the active site defined by Tyr 60, Tyr 239, and the polypeptide backbone [1].

Analytical, diagnostic and therapeutic context of l-benzylsuccinic acid

Binding of the biproduct analog L-benzylsuccinic acid to thermolysin determined by X-ray crystallography [2].
Titration of the azoenzyme with a series of synthetic, competitive inhibitors, e.g., L-benzylsuccinate, L-phenyllactate, and L-Phe, and with the pseudosubstrate, Gly-L-Tyr, in turn generates characteristic circular dichroic spectra [3].

References

Structure of the complex of L-benzylsuccinate with wheat serine carboxypeptidase II at 2.0-A resolution. Bullock, T.L., Branchaud, B., Remington, S.J. Biochemistry (1994) [Pubmed]
Binding of the biproduct analog L-benzylsuccinic acid to thermolysin determined by X-ray crystallography. Bolognesi, M.C., Matthews, B.W. J. Biol. Chem. (1979) [Pubmed]
Circular dichroism-inhibitor titrations of arsanilazotyrosine-248 carboxypeptidase A. Johansen, J.T., Klyosov, A.A., Vallee, B.L. Biochemistry (1976) [Pubmed]

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