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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

BFL     (2S)-2-(4- phenylphenyl)propanoic acid

Synonyms: SureCN7826539, AC1L9LHS, DB02047, 10532-14-6, UNII-E4ZV1V9C3W, ...
 
 
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Disease relevance of BFL

  • In addition, there is some evidence of type IV hypersensitivity in EAA and BFL, together with activation of complement via the alternative pathway (4, 8, 26) [1].
  • The effects of airway (AH) and vascular hypoxia (VH) on the production of nitric oxide (NO; VNO) were tested in isolated buffer-perfused (BFL) and blood-perfused rabbit lungs (BLL) [2].
 

High impact information on BFL

  • TIMP-3 promoter gene polymorphisms in BFL [3].
  • After extraction with hexane-diethyl ether (70:30, v/v) from plasma, BFL was analysed using a C18 Partisil 10 ODS-3 reversed-phase stainless steel column and a mobile phase of acetonitrile-0.1 M ammonium acetate (90:10, v/v) adjusted to pH 4.9 with ultraviolet detection at 335 nm [4].
  • Higher physiologic loads produced significant increases in overall deflection from BF to BFL alterations indicating a preference to preserve the posterior ligaments for this surgical approach [5].
  • The subjects with BFL were shown not to have an increased incidence of infections, and their response to infection did not differ from subjects having normal white blood cell counts [6].
  • This family suggests that the BFL gene product may play an important role in midline neuro-development including the hypothalamo-pituitary axis [7].
 

Gene context of BFL

  • HLA-G expression was studied using antibodies 4H84, G233, 87G, 16G1 and BFL [8].

References

  1. Type III allergy skin testing. Position statement for EAACI Subcommittee on Skin Tests and Allergen Standardization. Terho, E., Frew, A.J. Allergy (1995) [Pubmed]
  2. Regulation of pulmonary circulation by alveolar oxygen tension via airway nitric oxide. Ide, H., Nakano, H., Ogasa, T., Osanai, S., Kikuchi, K., Iwamoto, J. J. Appl. Physiol. (1999) [Pubmed]
  3. TIMP-3 promoter gene polymorphisms in BFL. Janssen, R., Kruit, A., Grutters, J.C., Ruven, H.J., van Moorsel, C.M., van den Bosch, J.M. Thorax (2005) [Pubmed]
  4. Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography. Mansor, S.M., Navaratnam, V., Yahaya, N., Nair, N.K., Wernsdorfer, W.H., Degen, P.H. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  5. The biomechanics of lumbar facetectomy under compression-flexion. Pintar, F.A., Cusick, J.F., Yoganandan, N., Reinartz, J., Mahesh, M. Spine. (1992) [Pubmed]
  6. Benign familial leukopenia and neutropenia in different ethnic groups. Shoenfeld, Y., Alkan, M.L., Asaly, A., Carmeli, Y., Katz, M. Eur. J. Haematol. (1988) [Pubmed]
  7. Borjeson-Forssman-Lehmann syndrome and multiple pituitary hormone deficiency. Birrell, G., Lampe, A., Richmond, S., Bruce, S.N., Gécz, J., Lower, K., Wright, M., Cheetham, T.D. Journal of pediatric endocrinology & metabolism : JPEM. (2003) [Pubmed]
  8. HLA Class I protein expression in the human placenta. Blaschitz, A., Hutter, H., Dohr, G. Early pregnancy (Online) (2001) [Pubmed]
 
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