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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

MOLI000038     methyl 3-(4-chlorophenyl)-8-(2...

Synonyms: MOLI001427, AC1L9NDJ, [18F]FECNT
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High impact information on MOLI001427


Anatomical context of MOLI001427

  • PET brain imaging studies in monkeys demonstrated high [18F]FECNT uptake in the caudate and putamen that resulted in caudate-to-cerebellum and putamen-to-cerebellum ratios of 10.5 at 60 min [2].

Gene context of MOLI001427

  • Blocking studies were performed in rats with a series of transporter-specific agents and demonstrated that the brain uptake of [18F]FECNT was selective and specific for DAT-rich regions [2].
  • Thus, [18F]FECNT appears to be an excellent agent for measuring plasma membrane-expressed DAT and evaluating DAT trafficking [1].


  1. Interaction of isoflurane with the dopamine transporter. Votaw, J., Byas-Smith, M., Hua, J., Voll, R., Martarello, L., Levey, A.I., Bowman, F.D., Goodman, M. Anesthesiology (2003) [Pubmed]
  2. 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Goodman, M.M., Kilts, C.D., Keil, R., Shi, B., Martarello, L., Xing, D., Votaw, J., Ely, T.D., Lambert, P., Owens, M.J., Camp, V.M., Malveaux, E., Hoffman, J.M. Nucl. Med. Biol. (2000) [Pubmed]
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