Disease relevance of Brain Mapping

• These results suggest that PET studies with [11C]PHY can provide in vivo brain mapping of human AChE and are promising for the study of changes in AChE levels associated with neurodegenerative diseases [1].
• This article is the fifth of a series aimed at mapping brain activities as they result from the development of cyclophosphamide (CP) cystitis in behaving rats using c-fos and Krox-24 expression [2].
• TMS motor cortical brain mapping in patients with complex regional pain syndrome type I [3].

Psychiatry related information on Brain Mapping

• We investigated quantitative EEG brain mapping as a physiologic marker of drug response while studying the stability of intersubject variability in patients with Alzheimer's disease (AD) who were receiving bethanechol through intracerebroventricular (ICV) shunts [4].
• 1. In a double-blind, placebo-controlled study the effects of venlafaxine--a novel nontricyclic compound inhibiting neuronal uptake of serotonin, noradrenaline and to a lesser extent dopamine--were investigated utilizing EEG brain mapping, psychometric and psychophysiological measures [5].
• We evaluated the effect of sleep fragmentation on brain function by measuring the visual P300 waveform using brain mapping [6].
• EEG and brain mapping (on basal conditions and after i.v. administration of diazepam) and visual, somatosensory and auditory evoked potentials have been performed on a patient at terminal evolution of CJD [7].
• Computerized EEG studies including evoked potentials (EP) or event-related potentials (ERP), spectral EEG analysis, and topographic EEG brain mapping have also identified a number of brain irregularities in individuals with learning disabilities, though no consistent exemplars have emerged [8].

High impact information on Brain Mapping

• The spatiotemporal evolution of the P300 waveform was topographically mapped in a group of ten male chronic schizophrenics, using the technique of brain electrical activity mapping [9].
• Functional brain mapping based on changes in local cerebral blood flow (lCBF) or glucose utilization (lCMR(glc)) induced by functional activation is generally carried out in animals under anesthesia, usually alpha-chloralose because of its lesser effects on cardiovascular, respiratory, and reflex functions [10].
• Human brain mapping in dystonia reveals both endophenotypic traits and adaptive reorganization [11].
• Extraction of clinical information from electroencephalographic background activity: the combined use of brain electrical activity mapping and intravenous sodium thiopental [12].
• The result of our study has clinical implications when MEG and fMRI localizations are used for pre- and intraoperative brain mapping [13].

Chemical compound and disease context of Brain Mapping

• Therapeutic effects of CDP-choline in Alzheimer's disease. Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors [14].

Biological context of Brain Mapping

• Multi-channel frequency analysis of electroencephalogram (electrophysiologic brain mapping) and recording of P300 and somatosensory evoked potentials were performed before, during and immediately after the hypoglycaemic period [15].
• We report cloning, pharmacological characterization, tissue distribution, detailed brain mapping, and role in control of food intake of melanocortin 4 receptor in goldfish (gMC4R) [16].
• Neurophysiologic assessment using topographic brain mapping demonstrated auditory evoked potential P300 asymmetry with left temporal inactivation and increased latency, while EEG frequency analysis was remarkable for left hemispheric slow wave predominance as well as increased left temporal beta activity [17].
• Comparative bioavailability studies with a new mixed-micelles solution of diazepam utilizing radioreceptor assay, psychometry and EEG brain mapping [18].

Anatomical context of Brain Mapping

• We found that 2-deoxyglucose brain mapping causes a progressive expansion of cortical representation of the spared vibrissae [19].
• The present study systematically and quantitatively analyzed the immunohistochemical distribution of various substances involved in synthesis, binding, and transport of dopamine in the forebrain of epileptic mice (EL mouse strain) using a brain mapping analyzer [20].

Associations of Brain Mapping with chemical compounds

• Spectroscopic brain mapping the N-acetyl aspartate to cognitive-perceptual states in chronic pain [21].
• A magnetic resonance (MR) imaging brain mapping method was used to localize an activated volume of brain tissue in chloralose-anesthetized rats during electrical stimulation of the forepaw [22].
• A new approach is proposed for registering a set of histological coronal two-dimensional images of a rat brain sectional material with coronal sections of a three-dimensional brain atlas, an intrinsic step and a significant challenge to current efforts in brain mapping and multimodal fusion of experimental data [23].
• EEG brain mapping in evaluating the time-course of the central action of DUP 996--a new acetylcholine releasing drug [24].
• Lithium: clinical study by brain electrical activity mapping. A case report [25].

Gene context of Brain Mapping

• The high specific activity one-step radiolabeling preparation and high selectivity of [(123)I]ZIENT for SERT support its candidacy as a radioligand for mapping brain SERT sites [26].
• The effect of the extracellular matrix recognition molecule tenascin-C on cerebral plasticity induced by vibrissectomy was investigated with 2-deoxyglucose (2DG) brain mapping in tenascin-C-deficient mice [27].
• These results indicate that [18F]FECNT is a radioligand that is superior to 11C-WIN 35,428, [11C]CIT/RTI-55, [18F]beta-CIT-FP, and [18F]FPCT for mapping brain DAT in humans using PET [28].
• Brain mapping techniques suggest that working memory, as measured by an A-X Continuous Performance Task, is important in ADHD [29].
• Measurement of relative cerebral blood flow (CBF) with 15O-labeled water PET has been widely used for brain mapping experiments on language functions in normal volunteers and patients with epilepsy [30].

Analytical, diagnostic and therapeutic context of Brain Mapping

• Molecular cloning, characterization and brain mapping of the melanocortin 5 receptor in the goldfish [31].
• The results of deprivation were assessed with 2-deoxyglucose functional brain-mapping autoradiography [32].
• Animal studies with different brain mapping techniques found that voluntary ethanol self-administration leads to changes in activity of specific brain regions in patterns that only partially overlap with patterns of brain regions affected by involuntary (i.e., experimenter-administered) ethanol administration [33].
• Synthesis of 3beta-(4-[18F]fluoromethylphenyl)- and 3beta-(2-[18F] fluoromethylphenyl)tropane-2beta-carboxylic acid methyl esters: new ligands for mapping brain dopamine transporter with positron emission tomography [34].

References