The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Tyroderm     3-[ (3R,6S,9S,12S,15S,17S,20S,22R, 25S,28S)...

Synonyms: Coltirot, Tyrozets, Martricin, Triciderm, Tyrosur, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of tyrothricin


High impact information on tyrothricin


Analytical, diagnostic and therapeutic context of tyrothricin

  • A rapid, sensitive, and accurate reversed-phase HPLC method has been developed for the analysis and quantification of pharmaceutical formulations containing tyrothricin (1), an antibiotic used in antiseptic buccal compressed tablets for local application [4].
  • The lozenge containing 10 mg tyrothricin was the most effective and was the only formulation capable of reducing oral aerobic bacterial counts by a factor of approximately 100 [5].
  • Salivary levels and total salivary recovery of gramicidin were determined by high performance liquid chromatography in healthy volunteers after administration of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash [6].


  1. Tyrothricin-containing oral tablets causing Clostridium Difficile-associated diarrhea. Demols, A., Van Gossum, A., Clevenberg, P., Thys, J.P., Liesnard, C. Dig. Dis. Sci. (1996) [Pubmed]
  2. In vitro antibacterial activity of gramicidin and tyrothricin. Ruckdeschel, G., Beaufort, F., Nahler, G., Belzer, O. Arzneimittel-Forschung. (1983) [Pubmed]
  3. Evaluation of topical pharyngeal anaesthesia by benzocaine lozenge for upper endoscopy. Shaoul, R., Higaze, H., Lavy, A. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  4. A rapid HPLC method for the quantification of tyrothricin, menthol, and benzocaine in pharmaceutical formulations. Caraballo, I., Fernandez-Arevalo, M., Holgado, M.A., Vela, M.T., Rabasco, A.M. Journal of pharmaceutical sciences. (1994) [Pubmed]
  5. Decontamination of the oral cavity. Effect of six local anti-microbial preparations in comparison to water and parafilm as controls. Matula, C., Hildebrandt, M., Nahler, G. J. Int. Med. Res. (1988) [Pubmed]
  6. Salivary levels of gramicidin after use of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash. Kreuzig, F., Nahler, G. International journal of clinical pharmacology research. (1983) [Pubmed]
WikiGenes - Universities