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Chemical Compound Review:

Tyroderm 3-[ (3R,6S,9S,12S,15S,17S,20S,22R, 25S,28S)...

Synonyms: Coltirot, Tyrozets, Martricin, Triciderm, Tyrosur, ...

Caraballo, I. et al., Kreuzig, F. et al., Shaoul, R. et al., Matula, C. et al., Ruckdeschel, G. et al., et al.

Shaoul, Higaze, Lavy,

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Disease relevance of tyrothricin

Tyrothricin-containing oral tablets causing Clostridium Difficile-associated diarrhea [1].
Haemophilus strains were mostly resistant to gramicidin and to a lesser extent to tyrothricin [2].

High impact information on tyrothricin

CONCLUSIONS: Topical pharyngeal anaesthesia with benzocaine/tyrothricin lozenges with conscious sedation has no advantages over conscious sedation alone in patients undergoing upper endoscopy [3].

Analytical, diagnostic and therapeutic context of tyrothricin

A rapid, sensitive, and accurate reversed-phase HPLC method has been developed for the analysis and quantification of pharmaceutical formulations containing tyrothricin (1), an antibiotic used in antiseptic buccal compressed tablets for local application [4].
The lozenge containing 10 mg tyrothricin was the most effective and was the only formulation capable of reducing oral aerobic bacterial counts by a factor of approximately 100 [5].
Salivary levels and total salivary recovery of gramicidin were determined by high performance liquid chromatography in healthy volunteers after administration of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash [6].

References

Tyrothricin-containing oral tablets causing Clostridium Difficile-associated diarrhea. Demols, A., Van Gossum, A., Clevenberg, P., Thys, J.P., Liesnard, C. Dig. Dis. Sci. (1996) [Pubmed]
In vitro antibacterial activity of gramicidin and tyrothricin. Ruckdeschel, G., Beaufort, F., Nahler, G., Belzer, O. Arzneimittel-Forschung. (1983) [Pubmed]
Evaluation of topical pharyngeal anaesthesia by benzocaine lozenge for upper endoscopy. Shaoul, R., Higaze, H., Lavy, A. Aliment. Pharmacol. Ther. (2006) [Pubmed]
A rapid HPLC method for the quantification of tyrothricin, menthol, and benzocaine in pharmaceutical formulations. Caraballo, I., Fernandez-Arevalo, M., Holgado, M.A., Vela, M.T., Rabasco, A.M. Journal of pharmaceutical sciences. (1994) [Pubmed]
Decontamination of the oral cavity. Effect of six local anti-microbial preparations in comparison to water and parafilm as controls. Matula, C., Hildebrandt, M., Nahler, G. J. Int. Med. Res. (1988) [Pubmed]
Salivary levels of gramicidin after use of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash. Kreuzig, F., Nahler, G. International journal of clinical pharmacology research. (1983) [Pubmed]

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