Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L9UO3 (2,4-dimethyl-1-oxido- pyridin-3-yl)-[4...

Synonyms:

Esté, J.A., Tagat, J.R. et al.

Esté, Tagat, Steensma, McCombie, Nazareno, Lin, Neustadt, Cox, Xu, Wojcik, Murray, Vantuno, Baroudy, Strizki,

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Disease relevance of AIDS-007877

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist [1].
By December 2001, a new phase I trial had been initiated in France. The company has continued to investigate a number of second-generation CCR5 receptor antagonists, including Sch-350634, for the potential treatment of HIV infection [2].

High impact information on AIDS-007877

Although it was reported at two separate meetings in early 2001 that Sch-350634 was in phase I/II trials, in April 2001, Schering-Plough confirmed that the compound was not in clinical development at that time and that a preclinical toxicology program was scheduled for late 2001 [2].

References

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist. Tagat, J.R., Steensma, R.W., McCombie, S.W., Nazareno, D.V., Lin, S.I., Neustadt, B.R., Cox, K., Xu, S., Wojcik, L., Murray, M.G., Vantuno, N., Baroudy, B.M., Strizki, J.M. J. Med. Chem. (2001) [Pubmed]
Sch-351125 and Sch-350634. Schering-Plough. Esté, J.A. Current opinion in investigational drugs (London, England : 2000) (2002) [Pubmed]

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