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Chemical Compound Review

Aplaviroc HCl     4-[4-[[1-butyl-3-[(R)- cyclohexyl-hydroxy...

Synonyms: AC1MHDOS, AC1OCFQR, AC1LAAV1, AK602, ONO 4128, ...
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Disease relevance of AK 602


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Gene context of AK 602


  1. Structural and Molecular Interactions of CCR5 Inhibitors with CCR5. Maeda, K., Das, D., Ogata-Aoki, H., Nakata, H., Miyakawa, T., Tojo, Y., Norman, R., Takaoka, Y., Ding, J., Arnold, G.F., Arnold, E., Mitsuya, H. J. Biol. Chem. (2006) [Pubmed]
  2. Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model. Nakata, H., Maeda, K., Miyakawa, T., Shibayama, S., Matsuo, M., Takaoka, Y., Ito, M., Koyanagi, Y., Mitsuya, H. J. Virol. (2005) [Pubmed]
  3. Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail. Johnson, B.M., Song, I.H., Adkison, K.K., Borland, J., Fang, L., Lou, Y., Berrey, M.M., Nafziger, A.N., Piscitelli, S.C., Bertino, J.S. Journal of clinical pharmacology. (2006) [Pubmed]
  4. The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects. Adkison, K.K., Shachoy-Clark, A., Fang, L., Lou, Y., Otto, V.R., Berrey, M.M., Piscitelli, S.C. British journal of clinical pharmacology. (2006) [Pubmed]
  5. CCR5 antagonists: host-targeted antivirals for the treatment of HIV infection. Westby, M., van der Ryst, E. Antivir. Chem. Chemother. (2005) [Pubmed]
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