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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1LAI5H     11-[hexadecanoyl-[2,3,5,6- tetrahydroxy-4...

Synonyms: CA52(n15)
 
 
 
 
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Disease relevance of AIDS-058992

 

High impact information on AIDS-058992

  • One of the soluble analogs, i.e. CA52(n15), strongly inhibited the binding of [3H]suramin to the V3 peptide, with an IC50 of 1.2 microM [1].
  • Using a competition enzyme-linked immunosorbent assay with highly specific anti-gp120 monoclonal antibodies, the region recognized by CA52(n15) could be mapped to amino acids 318-323, which corresponds to the highly conserved consensus motif GPGRAF [1].

References

  1. Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV-1 gp120 and inhibit HIV-1-induced fusion and entry. Fantini, J., Hammache, D., Delézay, O., Yahi, N., André-Barrès, C., Rico-Lattes, I., Lattes, A. J. Biol. Chem. (1997) [Pubmed]
 
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