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MeSH Review

Cell Fusion

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Disease relevance of Cell Fusion


Psychiatry related information on Cell Fusion

  • In a previous study using somatic cell fusion for Ig chain recombination we demonstrated that a recombinant antibody consisting of the H chain of antibody 26-10 and the L chain of antibody 40-20 retained digoxin binding and the 26-10 Id, but displayed a binding specificity pattern dominated by the 26-10 H chain donor [6].

High impact information on Cell Fusion

  • We conclude from our results that the KAR1, CDC28, and CDC37 gene products can diffuse between nuclei in a heterocaryon and that they probably perform their function for caryogamy prior to cell fusion [7].
  • Modulation and mapping of a human plasminogen activator by cell fusion [8].
  • We also show that the haematopoietic donor genome adopts a more hepatocyte-specific expression profile after cell fusion, as the wild-type Fah gene was activated and the pan-haematopoietic CD45 marker was no longer expressed [9].
  • To test whether this resulted from the differences in virus structure or the capacity of MV to induce cell fusion and/or immunosuppression, we analyzed antibody responses to chimeric MV expressing VSV glycoprotein instead of MV fusion protein and hemagglutinin [10].
  • Coupling of hormone receptors to adenylate cyclase of different cells by cell fusion [11].

Chemical compound and disease context of Cell Fusion


Biological context of Cell Fusion


Anatomical context of Cell Fusion


Associations of Cell Fusion with chemical compounds


Gene context of Cell Fusion

  • We found that polarisome components and the cell fusion proteins Fus1 and Fus2 are important for the termination of projection growth [28].
  • Fus3p, a pheromone-activated MAP kinase, is required for pheromone signaling and cell fusion [29].
  • Overexpression of KEL1 also suppressed the defect in cell fusion of spa2Delta and fps1Delta mutants [19].
  • Two lines of evidence indicate that RVS161/END6's endocytic function is not required for cell fusion [30].
  • Fig1p and Fig2p are also important for cell fusion and conjugation bridge shape, respectively [31].

Analytical, diagnostic and therapeutic context of Cell Fusion


  1. The secret life of ACE2 as a receptor for the SARS virus. Dimitrov, D.S. Cell (2003) [Pubmed]
  2. CD46 is a cellular receptor for human herpesvirus 6. Santoro, F., Kennedy, P.E., Locatelli, G., Malnati, M.S., Berger, E.A., Lusso, P. Cell (1999) [Pubmed]
  3. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques. Watanabe, M., Reimann, K.A., DeLong, P.A., Liu, T., Fisher, R.A., Letvin, N.L. Nature (1989) [Pubmed]
  4. Role of envelope glycoprotein carbohydrate in human immunodeficiency virus (HIV) infectivity and virus-induced cell fusion. Lifson, J., Coutré, S., Huang, E., Engleman, E. J. Exp. Med. (1986) [Pubmed]
  5. Measles virus-substance P receptor interactions. Possible novel mechanism of viral fusion. Harrowe, G., Mitsuhashi, M., Payan, D.G. J. Clin. Invest. (1990) [Pubmed]
  6. A V kappa-J kappa junctional change in an antidigoxin recombinant antibody destroys digoxin-binding activity. Hudson, N.W., Bruccoleri, R.E., Steinrauf, L.K., Hamilton, J.A., Mudgett-Hunter, M., Margolies, M.N. J. Immunol. (1990) [Pubmed]
  7. Genes that act before conjugation to prepare the Saccharomyces cerevisiae nucleus for caryogamy. Dutcher, S.K., Hartwell, L.H. Cell (1983) [Pubmed]
  8. Modulation and mapping of a human plasminogen activator by cell fusion. Kucherlapati, R., Tepper, R., Granelli-Piperno, A., Reich, E. Cell (1978) [Pubmed]
  9. Transplanted bone marrow regenerates liver by cell fusion. Vassilopoulos, G., Wang, P.R., Russell, D.W. Nature (2003) [Pubmed]
  10. T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses. Fehr, T., Naim, H.Y., Bachmann, M.F., Ochsenbein, A.F., Spielhofer, P., Bucher, E., Hengartner, H., Billeter, M.A., Zinkernagel, R.M. Nat. Med. (1998) [Pubmed]
  11. Coupling of hormone receptors to adenylate cyclase of different cells by cell fusion. Schramm, M., Orly, J., Eimerl, S., Korner, M. Nature (1977) [Pubmed]
  12. Interplay between lipids and viral glycoproteins during hemolysis and fusion by influenza virus. Huang, R.T., Uslu, G. J. Biol. Chem. (1986) [Pubmed]
  13. Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man3GlcNAc2: structural basis for specificity and high-affinity binding to the core pentasaccharide from n-linked oligomannoside. Williams, D.C., Lee, J.Y., Cai, M., Bewley, C.A., Clore, G.M. J. Biol. Chem. (2005) [Pubmed]
  14. Measles virus fusion protein is palmitoylated on transmembrane-intracytoplasmic cysteine residues which participate in cell fusion. Caballero, M., Carabaña, J., Ortego, J., Fernández-Muñoz, R., Celma, M.L. J. Virol. (1998) [Pubmed]
  15. Effects of 2-deoxyglucose, glucosamine, and mannose on cell fusion and the glycoproteins of herpes simplex virus. Knowles, R.W., Person, S. J. Virol. (1976) [Pubmed]
  16. Normalization by cell fusion of sister chromatid exchange in Bloom syndrome lymphocytes. Shiraishi, Y., Matsui, S., Sandberg, A.A. Science (1981) [Pubmed]
  17. LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion. Shemer, G., Podbilewicz, B. Genes Dev. (2002) [Pubmed]
  18. Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. Perfettini, J.L., Castedo, M., Nardacci, R., Ciccosanti, F., Boya, P., Roumier, T., Larochette, N., Piacentini, M., Kroemer, G. J. Exp. Med. (2005) [Pubmed]
  19. Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. Philips, J., Herskowitz, I. J. Cell Biol. (1998) [Pubmed]
  20. Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context. Renshaw, M.W., Kipreos, E.T., Albrecht, M.R., Wang, J.Y. EMBO J. (1992) [Pubmed]
  21. Regulation of muscle differentiation: stimulation of myoblast fusion in vitro by catecholamines. Curtis, D.H., Zalin, R.J. Science (1981) [Pubmed]
  22. The homeotic gene lin-39 and the evolution of nematode epidermal cell fates. Eizinger, A., Sommer, R.J. Science (1997) [Pubmed]
  23. Mesenchymal stem cells are recruited to striated muscle by NFAT/IL-4-mediated cell fusion. Schulze, M., Belema-Bedada, F., Technau, A., Braun, T. Genes Dev. (2005) [Pubmed]
  24. Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma x T cell hybrids. Radomska, H.S., Shen, C.P., Kadesch, T., Eckhardt, L.A. Immunity (1994) [Pubmed]
  25. LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells. Marlin, S.D., Morton, C.C., Anderson, D.C., Springer, T.A. J. Exp. Med. (1986) [Pubmed]
  26. Diazepam inhibits myoblast fusion and expression of muscle specific protein synthesis. Bandman, E., Walker, C.R., Strohman, R.C. Science (1978) [Pubmed]
  27. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Feng, Y., Broder, C.C., Kennedy, P.E., Berger, E.A. Science (1996) [Pubmed]
  28. Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators. Bidlingmaier, S., Snyder, M. J. Cell Biol. (2004) [Pubmed]
  29. Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p. Matheos, D., Metodiev, M., Muller, E., Stone, D., Rose, M.D. J. Cell Biol. (2004) [Pubmed]
  30. Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae. Brizzio, V., Gammie, A.E., Rose, M.D. J. Cell Biol. (1998) [Pubmed]
  31. Pheromone-regulated genes required for yeast mating differentiation. Erdman, S., Lin, L., Malczynski, M., Snyder, M. J. Cell Biol. (1998) [Pubmed]
  32. Fusigenic viral liposome for gene therapy in cardiovascular diseases. Dzau, V.J., Mann, M.J., Morishita, R., Kaneda, Y. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  33. Differential effects of calcium ion concentration on cell fusion, cell division and creatine kinase activity in mucle cell cultures. Morris, G.E., Piper, M., Cole, R. Exp. Cell Res. (1976) [Pubmed]
  34. Early initiation of DNA synthesis in G1 phase HeLa cells following fusion with red cell ghosts loaded with S-phase cell extracts. Brown, D.B., Hanks, S.K., Murphy, E.C., Rao, P.N. Exp. Cell Res. (1985) [Pubmed]
  35. Activation of T cell cytotoxicity against autologous common acute lymphoblastic leukemia (cALL) blasts by CD3xCD19 bispecific antibody. Csóka, M., Strauss, G., Debatin, K.M., Moldenhauer, G. Leukemia (1996) [Pubmed]
  36. Juvenile Sandhoff Disease: complementation tests with Sandhoff and Tay-Sachs disease using polyethylene glycol-induced cell fusion. Wood, S. Hum. Genet. (1978) [Pubmed]
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