Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Canophyllol (4R,4aS,6aS,6bR,8aR,14aS)- 8a...

Synonyms: AC1LAJU4, AG-K-52050, CTK7J6923

Dharmaratne, H.R. et al., Huerta-Reyes, M. et al., Mitaine-Offer, A.C. et al.

Mitaine-Offer, Hornebeck, Sauvain, Zèches-Hanrot,

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Disease relevance of AIDS-060363

In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity [1].

High impact information on AIDS-060363

In this series, lupeol, ursolic acid and canophyllol showed marked HLE inhibitory activity with IC(50) values at 1.9 microM, 4.4 microM, and 2.5 microM, respectively [2].
Twigs of Calophyllum cordato-oblongum have been shown to contain a new pyranocoumarin, the methyl ether of cordatolide B, three reported pyranocoumarins, cordato-oblongic acid, friedelin, canophyllol and taraxerol [3].

References

HIV-1 inhibitory compounds from Calophyllum brasiliense leaves. Huerta-Reyes, M., Basualdo, M.d.e.l. .C., Abe, F., Jimenez-Estrada, M., Soler, C., Reyes-Chilpa, R. Biol. Pharm. Bull. (2004) [Pubmed]
Triterpenes and phytosterols as human leucocyte elastase inhibitors. Mitaine-Offer, A.C., Hornebeck, W., Sauvain, M., Zèches-Hanrot, M. Planta Med. (2002) [Pubmed]
Distribution of pyranocoumarins in Calophyllum cordato-oblongum. Dharmaratne, H.R., Mayuri Sajeevani, J.R., Marasinghe, G.P., Shantha Ekanayake, E.M. Phytochemistry (1998) [Pubmed]

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