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Chemical Compound Review

Amentoflavone     8-[5-(5,7-dihydroxy-4-oxo- chromen-2-yl)-2...

Synonyms: Amenthoflavone, AC1NQYPA, CHEMBL63354, SureCN312563, CHEBI:2631, ...
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Disease relevance of C10018


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Biological context of C10018


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Gene context of C10018


Analytical, diagnostic and therapeutic context of C10018

  • Quantification of amentoflavone was carried out by reversed phase HPLC in methanolic and aqueous extracts of the roots, stems and leaves [20].


  1. Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms. Shin, D.H., Bae, Y.C., Kim-Han, J.S., Lee, J.H., Choi, I.Y., Son, K.H., Kang, S.S., Kim, W.K., Han, B.H. J. Neurochem. (2006) [Pubmed]
  2. Effects of St. John's Wort Extract and Single Constituents on Stress-Induced Hyperthermia in Mice. Grundmann, O., Kelber, O., Butterweck, V. Planta Med. (2006) [Pubmed]
  3. Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells. Banerjee, T., Valacchi, G., Ziboh, V.A., van der Vliet, A. Mol. Cell. Biochem. (2002) [Pubmed]
  4. Neuroprotective effects of naturally occurring biflavonoids. Kang, S.S., Lee, J.Y., Choi, Y.K., Song, S.S., Kim, J.S., Jeon, S.J., Han, Y.N., Son, K.H., Han, B.H. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  5. Interactions of the monomeric and dimeric flavones apigenin and amentoflavone with the plasma membrane of L929 cells; a fluorescence study. Lenne-Gouverneur, A.F., Lobstein, A., Haan-Archipoff, G., Duportail, G., Anton, R., Kuhry, J.G. Mol. Membr. Biol. (1999) [Pubmed]
  6. Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Banerjee, T., Van der Vliet, A., Ziboh, V.A. Prostaglandins Leukot. Essent. Fatty Acids (2002) [Pubmed]
  7. Vasorelaxation by amentoflavone isolated from Selaginella tamariscina. Kang, D.G., Yin, M.H., Oh, H., Lee, D.H., Lee, H.S. Planta Med. (2004) [Pubmed]
  8. Inhibition of human cytochromes P450 by components of Ginkgo biloba. von Moltke, L.L., Weemhoff, J.L., Bedir, E., Khan, I.A., Harmatz, J.S., Goldman, P., Greenblatt, D.J. J. Pharm. Pharmacol. (2004) [Pubmed]
  9. Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana. Lee, M.K., Lim, S.W., Yang, H., Sung, S.H., Lee, H.S., Park, M.J., Kim, Y.C. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  10. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Woo, E.R., Lee, J.Y., Cho, I.J., Kim, S.G., Kang, K.W. Pharmacol. Res. (2005) [Pubmed]
  11. Transport of amentoflavone across the blood-brain barrier in vitro. Gutmann, H., Bruggisser, R., Schaffner, W., Bogman, K., Botomino, A., Drewe, J. Planta Med. (2002) [Pubmed]
  12. Isolation of amentoflavone from Selaginella rupestris and its pharmacological activity on central nervous system, smooth muscles and isolated frog heart preparations. Chakravarthy, B.K., Rao, Y.V., Gambhir, S.S., Gode, K.D. Planta Med. (1981) [Pubmed]
  13. Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Hanrahan, J.R., Chebib, M., Davucheron, N.L., Hall, B.J., Johnston, G.A. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  14. Inhibition of human platelet cyclic AMP phosphodiesterase and of platelet aggregation by a hemisynthetic flavonoid, amentoflavone hexaacetate. Beretz, A., Briançon-Scheid, F., Stierlé, A., Corre, G., Anton, R., Cazenave, J.P. Biochem. Pharmacol. (1986) [Pubmed]
  15. Quantitative phytochemical analyses of six hypericum species growing in slovenia. Umek, A., Kreft, S., Kartnig, T., Heydel, B. Planta Med. (1999) [Pubmed]
  16. Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort. Williams, F.B., Sander, L.C., Wise, S.A., Girard, J. Journal of chromatography. A. (2006) [Pubmed]
  17. Biflavonoids from Cycas beddomei. Das, B., Mahender, G., Koteswara Rao, Y., Prabhakar, A., Jagadeesh, B. Chem. Pharm. Bull. (2005) [Pubmed]
  18. Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. Baureithel, K.H., Büter, K.B., Engesser, A., Burkard, W., Schaffner, W. Pharmaceutica acta Helvetiae. (1997) [Pubmed]
  19. Protein Tyrosine Phosphatase 1B Inhibitory Activity of Amentoflavone and Its Cellular Effect on Tyrosine Phosphorylation of Insulin Receptors. Na, M., Kim, K.A., Oh, H., Kim, B.Y., Oh, W.K., Ahn, J.S. Biol. Pharm. Bull. (2007) [Pubmed]
  20. Amentoflavone from Biophytum sensitivum and its Effect on COX-1/COX-2 Catalysed Prostaglandin Biosynthesis. Bucar, F., Jachak, S.M., Noreem, Y., Kartnig, T., Perera, P., Bohlin, L., Schubert-Zsilavecz, M. Planta Med. (1998) [Pubmed]
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