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Chemical Compound Review

Nizoral     1-[4-[4-[[(2R,4R)-2-(2,4- dichlorophenyl)-2...

Synonyms: Brizoral, Fungoral, Ketoderm, Ketozole, Sebazole, ...
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Disease relevance of ketoconazole


High impact information on ketoconazole

  • Using only the in vitro assessment with the criteria of steroid biosynthesis inhibition, four of nine compounds were correctly identified in the testis explant assay (17beta-E2, KETO, FLUT, and HALO) [2].
  • These results suggest that MCZ, but not KCZ, has inducing activity for hepatic cytochrome P-450-dependent oxidative metabolism of steroids and xenobiotics, in addition to its known inhibitory activity [3].

Analytical, diagnostic and therapeutic context of ketoconazole

  • KTCZ exposure alone drove a 3-fold increase in serum LH concentrations (P < 10(-3)) and a 2.5-fold rise in FSH secretion (P = 0.015), as assessed by high-specificity immunoradiometric assays [4].
  • The addition of concentrations of TC above the CMC in the perfusion solution resulted in a reduction of the absorption rate of GF and KE [5].


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