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Chemical Compound Review

BICIFADINE     1-(4-methylphenyl)-3- azabicyclo[3.1.0]hexane

Synonyms: Bicifadino, Bicifadinum, PubChem18323, SureCN38793, AGN-PC-00EOS1, ...
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Disease relevance of BICIFADINE


High impact information on BICIFADINE


Analytical, diagnostic and therapeutic context of BICIFADINE

  • Bicifadine, 1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man [3].


  1. The oral analgesic efficacy of bicifadine hydrochloride in postoperative pain. Wang, R.I., Johnson, R.P., Lee, J.C., Waite, E.M. Journal of clinical pharmacology. (1982) [Pubmed]
  2. Determination of the polymorphic forms of bicifadine hydrochloride by differential scanning calorimetry-thermogravimetric analysis, X-ray powder diffraction, attenuated total reflectance-infrared spectroscopy, and attenuated total reflectance-near-infrared spectroscopy. McArdle, P., Gilligan, K., Cunningham, D., Ryder, A. Applied spectroscopy. (2005) [Pubmed]
  3. 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. Epstein, J.W., Brabander, H.J., Fanshawe, W.J., Hofmann, C.M., McKenzie, T.C., Safir, S.R., Osterberg, A.C., Cosulich, D.B., Lovell, F.M. J. Med. Chem. (1981) [Pubmed]
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