Disease relevance of Glabrene

• The effect of increasing concentrations of glabrene and ILC on the growth of breast tumor cell were biphasic [1].
• We describe here the antimutagenic potential of Glabrene analogs against EMS-induced mutations utilizing modified Ames tests in S. typhimurium TA 100 and E. coli JC 5088 [2].

High impact information on Glabrene

• In the present study, we tested the effects on vascular tissues in vitro and in vivo of two natural compounds derived from licorice root: glabridin, the major isoflavan, and glabrene, an isoflavene, both demonstrated estrogen-like activities [3].
• Both glabridin and glabrene stimulated creatine kinase specific activity in diaphyseal bone and epiphyseal cartilage of prepubertal female rats [4].
• Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues [4].
• This is the first study to indicate that glabrene, an isoflavene exerted varying degrees of ER agonism in different tissues [1].
• The effects of glabrene and isoliquiritigenin on tyrosinase activity were dose-dependent and correlated to their ability to inhibit melanin formation in melanocytes [5].

References