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Chemical Compound Review

ISLQ     (E)-1-(2,4-dihydroxyphenyl)- 3-(4...

Synonyms: GU-17, PubChem21917, S2404_Selleck, CHEMBL129795, SureCN161168, ...
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Disease relevance of isoliquiritigenin


High impact information on isoliquiritigenin


Chemical compound and disease context of isoliquiritigenin


Biological context of isoliquiritigenin


Anatomical context of isoliquiritigenin


Associations of isoliquiritigenin with other chemical compounds


Gene context of isoliquiritigenin


Analytical, diagnostic and therapeutic context of isoliquiritigenin


  1. Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling. Kim, D.C., Choi, S.Y., Kim, S.H., Yun, B.S., Yoo, I.D., Reddy, N.R., Yoon, H.S., Kim, K.T. Mol. Pharmacol. (2006) [Pubmed]
  2. Molecular characterization and expression of alfalfa isoliquiritigenin 2'-O-methyltransferase, an enzyme specifically involved in the biosynthesis of an inducer of Rhizobium meliloti nodulation genes. Maxwell, C.A., Harrison, M.J., Dixon, R.A. Plant J. (1993) [Pubmed]
  3. The potent anti-tumor-promoting agent isoliquiritigenin. Yamamoto, S., Aizu, E., Jiang, H., Nakadate, T., Kiyoto, I., Wang, J.C., Kato, R. Carcinogenesis (1991) [Pubmed]
  4. Isoliquiritigenin inhibits the growth of prostate cancer. Kanazawa, M., Satomi, Y., Mizutani, Y., Ukimura, O., Kawauchi, A., Sakai, T., Baba, M., Okuyama, T., Nishino, H., Miki, T. Eur. Urol. (2003) [Pubmed]
  5. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. Jez, J.M., Noel, J.P. J. Biol. Chem. (2002) [Pubmed]
  6. Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures. Ichimura, M., Furuno, T., Takahashi, T., Dixon, R.A., Ayabe, S. Phytochemistry (1997) [Pubmed]
  7. Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma. Yamazaki, S., Morita, T., Endo, H., Hamamoto, T., Baba, M., Joichi, Y., Kaneko, S., Okada, Y., Okuyama, T., Nishino, H., Tokue, A. Cancer Lett. (2002) [Pubmed]
  8. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Iwashita, K., Kobori, M., Yamaki, K., Tsushida, T. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  9. Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. Ma, J., Fu, N.Y., Pang, D.B., Wu, W.Y., Xu, A.L. Planta Med. (2001) [Pubmed]
  10. Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. Hsu, Y.L., Kuo, P.L., Lin, L.T., Lin, C.C. Planta Med. (2005) [Pubmed]
  11. Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. Tawata, M., Aida, K., Noguchi, T., Ozaki, Y., Kume, S., Sasaki, H., Chin, M., Onaya, T. Eur. J. Pharmacol. (1992) [Pubmed]
  12. Isoliquiritigenin, a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. Kape, R., Parniske, M., Brandt, S., Werner, D. Appl. Environ. Microbiol. (1992) [Pubmed]
  13. Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC-polyurethane membranes. De Bartolo, L., Morelli, S., Gallo, M.C., Campana, C., Statti, G., Rende, M., Salerno, S., Drioli, E. Biomaterials (2005) [Pubmed]
  14. Simultaneous quantification of multiple licorice flavonoids in rat plasma. Li, L., Liang, S., Du, F., Li, C. J. Am. Soc. Mass Spectrom. (2007) [Pubmed]
  15. Estrogen-like activity of glabrene and other constituents isolated from licorice root. Tamir, S., Eizenberg, M., Somjen, D., Izrael, S., Vaya, J. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  16. Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.). Maxwell, C.A., Edwards, R., Dixon, R.A. Arch. Biochem. Biophys. (1992) [Pubmed]
  17. Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells. Maggiolini, M., Statti, G., Vivacqua, A., Gabriele, S., Rago, V., Loizzo, M., Menichini, F., Amdò, S. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  18. Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells. Hsu, Y.L., Kuo, P.L., Lin, C.C. Life Sci. (2005) [Pubmed]
  19. Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation. An, W., Yang, J., Ao, Y. Acta Pharmacol. Sin. (2006) [Pubmed]
  20. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. Kwon, H.M., Choi, Y.J., Choi, J.S., Kang, S.W., Bae, J.Y., Kang, I.J., Jun, J.G., Lee, S.S., Lim, S.S., Kang, Y.H. Exp. Biol. Med. (Maywood) (2007) [Pubmed]
  21. Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. Cao, Y., Wang, Y., Ji, C., Ye, J. Journal of chromatography. A. (2004) [Pubmed]
  22. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). Jang, D.S., Park, E.J., Hawthorne, M.E., Vigo, J.S., Graham, J.G., Cabieses, F., Santarsiero, B.D., Mesecar, A.D., Fong, H.H., Mehta, R.G., Pezzuto, J.M., Kinghorn, A.D. J. Nat. Prod. (2003) [Pubmed]
  23. Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin. Ii, T., Satomi, Y., Katoh, D., Shimada, J., Baba, M., Okuyama, T., Nishino, H., Kitamura, N. Cancer Lett. (2004) [Pubmed]
  24. Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis. Baba, M., Asano, R., Takigami, I., Takahashi, T., Ohmura, M., Okada, Y., Sugimoto, H., Arika, T., Nishino, H., Okuyama, T. Biol. Pharm. Bull. (2002) [Pubmed]
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