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Chemical Compound Review

Moronicacid     (4aS,6aR,6aR,6bR,8aR,12aR,14aS )-2,2,6a,6b...

Synonyms: AC1LAKJE, Moronic acid, CHEMBL472646, SureCN324972, CHEBI:30815, ...
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Disease relevance of AIDS-113489

  • Among them, moronic acid derivatives 19, 20, and 21 showed significant activity in HIV-1 infected H9 lymphocytes [1].
  • The effective concentrations for 50% plaque reduction of moronic acid and betulonic acid for wild-type HSV type 1 (HSV-1) were 3.9 and 2.6 microgram/ml, respectively [2].

High impact information on AIDS-113489

  • Susceptibility of acyclovir-phosphonoacetic acid-resistant HSV-1, thymidine kinase-deficient HSV-1, and wild-type HSV type 2 to moronic acid was similar to that of the wild-type HSV-1 [2].
  • We purified two major anti-HSV compounds, moronic acid and betulonic acid, from the herbal extract by extraction with ethyl acetate at pH 10 followed by chromatographic separations and examined their anti-HSV activity in vitro and in vivo [2].


  1. Anti-AIDS agents 69. moronic acid and other triterpene derivatives as novel potent anti-HIV agents. Yu, D., Sakurai, Y., Chen, C.H., Chang, F.R., Huang, L., Kashiwada, Y., Lee, K.H. J. Med. Chem. (2006) [Pubmed]
  2. Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo. Kurokawa, M., Basnet, P., Ohsugi, M., Hozumi, T., Kadota, S., Namba, T., Kawana, T., Shiraki, K. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
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