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Chemical Compound Review

AC1LAPYA     3-[2-[[3- (diaminomethylideneamino) phenyl]c...

Synonyms: SureCN244261, SC-68448, SC68448
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Disease relevance of SC-68448


High impact information on SC-68448

  • One of these compounds, beta-[[2-2-[[[3-[(aminoiminomethyl)amino]-phenyl]carbonyl]amino]ac etyl]amino]-3,5-dichlorobenzenepropanoic acid (SC-68448), inhibited vitronectin binding to both alpha(v)beta3 and the closely related platelet receptor, alpha(IIb)beta3, in a dose-responsive manner [1].
  • In cell-based studies, SC-68448 inhibited alpha(v)beta3-mediated endothelial cell proliferation in a dose-dependent manner but did not inhibit tumor cell proliferation, suggesting that effects on endothelial cell proliferation were not due to SC-68448-induced cytotoxicity [1].

Biological context of SC-68448

  • SC-68448 inhibited vitronectin binding to alpha(v)beta3 (IC50, 1 nM) and fibrinogen binding to the platelet receptor alpha(IIb)beta3 (IC50, >100 nM), demonstrating that SC-68448 was 100-fold more potent as an inhibitor of alpha(v)beta3 versus alpha(IIb)beta3 [1].


  1. A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Carron, C.P., Meyer, D.M., Pegg, J.A., Engleman, V.W., Nickols, M.A., Settle, S.L., Westlin, W.F., Ruminski, P.G., Nickols, G.A. Cancer Res. (1998) [Pubmed]
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