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MeSH Review

Leydig Cell Tumor

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Disease relevance of Leydig Cell Tumor


High impact information on Leydig Cell Tumor


Chemical compound and disease context of Leydig Cell Tumor


Biological context of Leydig Cell Tumor


Anatomical context of Leydig Cell Tumor


Gene context of Leydig Cell Tumor


Analytical, diagnostic and therapeutic context of Leydig Cell Tumor

  • Passive immunization using antisera raised against rat PTH-like peptide [PLP-(1-34)] and rat PTH-(1-84) was used to assess and compare the roles played by PLP and PTH in modulating mineral metabolism in hypercalcemic rats bearing the Rice-500 Leydig cell tumor and in normocalcemic control animals [29].


  1. A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo. Haq, M., Kremer, R., Goltzman, D., Rabbani, S.A. J. Clin. Invest. (1993) [Pubmed]
  2. Cross-reactivity of a monoclonal antibody directed against an estrogen-induced protein in MCF-7 human breast cancer cells with murine Leydig cell tumor proteins. Melner, M.H., Voigt, W., Puett, D. Cancer Res. (1986) [Pubmed]
  3. Synergistic effects of inhibins and müllerian-inhibiting substance on testicular tumorigenesis. Matzuk, M.M., Finegold, M.J., Mishina, Y., Bradley, A., Behringer, R.R. Mol. Endocrinol. (1995) [Pubmed]
  4. Epidermal growth factor receptor expression and activation in nonseminomatous germ cell tumors. Moroni, M., Veronese, S., Schiavo, R., Carminati, O., Sorensen, B.S., Gambacorta, M., Siena, S. Clin. Cancer Res. (2001) [Pubmed]
  5. Detection of RAS mutations in archival testicular germ cell tumors by polymerase chain reaction and oligonucleotide hybridization. Moul, J.W., Theune, S.M., Chang, E.H. Genes Chromosomes Cancer (1992) [Pubmed]
  6. Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. Pedersen, R.C., Brownie, A.C. Science (1987) [Pubmed]
  7. Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats. Peterson, J.E., Jago, M.V., Reddy, J.K., Jarrett, R.G. J. Natl. Cancer Inst. (1983) [Pubmed]
  8. Carcinogen bioassay and mutagenicity studies with the hypolipidemic agent gemfibrozil. Fitzgerald, J.E., Sanyer, J.L., Schardein, J.L., Lake, R.S., McGuire, E.J., de la Iglesia, F.A. J. Natl. Cancer Inst. (1981) [Pubmed]
  9. Autoradiographic evidence for the association of DNA with intracytoplasmic A-particle inclusions in situ. Smith, G.H., Longfellow, D.G., Nixon, J.W. J. Natl. Cancer Inst. (1975) [Pubmed]
  10. Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides. Baenziger, J.U., Kumar, S., Brodbeck, R.M., Smith, P.L., Beranek, M.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Characterization of estrogen receptors in various mouse Leydig cell tumor lines. Sato, B., Huseby, R.A., Samuels, L.T. Cancer Res. (1978) [Pubmed]
  12. Gonadotropin-induced proliferation of endoplasmic reticulum in an androgenic tumor and its relation to elevated plasma testosterone levels. Neaves, W.B. Cancer Res. (1975) [Pubmed]
  13. Stimulative effects of estrogens on tumor growth and 5 alpha-steroid production in a mouse Leydig cell tumor line (T 124958-R). Noguchi, S., Nishizawa, Y., Takatsuka, D., Sato, B., Matsumoto, K. Cancer Res. (1986) [Pubmed]
  14. Effects of tamoxifen on estrogen-induced enhancement or inhibition of tumor growth in mouse Leydig cell tumor lines. Sato, B., Maeda, Y., Nishizawa, Y., Noma, K., Kishimoto, S., Matsumoto, K. Cancer Res. (1984) [Pubmed]
  15. A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Carron, C.P., Meyer, D.M., Pegg, J.A., Engleman, V.W., Nickols, M.A., Settle, S.L., Westlin, W.F., Ruminski, P.G., Nickols, G.A. Cancer Res. (1998) [Pubmed]
  16. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Yasuda, T., Banville, D., Rabbani, S.A., Hendy, G.N., Goltzman, D. Mol. Endocrinol. (1989) [Pubmed]
  17. Autocrine regulation of cell proliferation by estradiol and hydroxytamoxifen of transformed mouse Leydig cells in serum-free culture. Nishizawa, Y., Sato, B., Miyashita, Y., Tsukada, S., Hirose, T., Kishimoto, S., Matsumoto, K. Endocrinology (1988) [Pubmed]
  18. Evidence that Leydig cells in Sertoli-Leydig cell tumors have a reactive rather than a neoplastic profile. Mooney, E.E., Man, Y.G., Bratthauer, G.L., Tavassoli, F.A. Cancer (1999) [Pubmed]
  19. Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies. Brüning, T., Bolt, H.M. Crit. Rev. Toxicol. (2000) [Pubmed]
  20. Epidermal growth factor and cyclic AMP stimulation of distinct protein kinase activities in Leydig cell tumor membranes. Melner, M.H., Lutin, W.A., Puett, D. Life Sci. (1982) [Pubmed]
  21. Comparative study on metallothionein induction in whole testicular tissue and isolated Leydig cells. Abel, J., de Ruiter, N., Kühn-Velten, W.N. Arch. Toxicol. (1991) [Pubmed]
  22. Detection of estrogen receptor-like high affinity components by exposure of cytosols from mouse Leydig cell tumor or male rat liver to chaotropic salts. Sato, B., Nishizawa, Y., Maeda, Y., Noma, K., Matsumoto, K., Yamamura, Y. J. Steroid Biochem. (1981) [Pubmed]
  23. Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Sato, K., Ueda, Y., Sakurai, A., Ishikawa, Y., Okamoto, S.Y., Ikawa, H., Katsuda, S. Pathol. Int. (2005) [Pubmed]
  24. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. Gaytan, F., Barreiro, M.L., Caminos, J.E., Chopin, L.K., Herington, A.C., Morales, C., Pinilla, L., Paniagua, R., Nistal, M., Casanueva, F.F., Aguilar, E., Diéguez, C., Tena-Sempere, M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  25. An in vivo model for receptor tyrosine kinase autocrine/paracrine activation: auto-stimulated KIT receptor acts as a tumor promoting factor in papillomavirus-induced tumorigenesis. Kondoh, G., Hayasaka, N., Li, Q., Nishimune, Y., Hakura, A. Oncogene (1995) [Pubmed]
  26. Effect of 4-hydroxyandrostenedione on murine Leydig tumor cell steroidogenesis. Zimniski, S.J., Brandt, M.E., Melner, M.H., Brodie, A.M., Puett, D. Cancer Res. (1991) [Pubmed]
  27. Measurement of circulating parathyroid hormone-related protein in rats with humoral hypercalcemia of malignancy using a two-site immunoradiometric assay. Gaich, G., Burtis, W.J. Endocrinology (1990) [Pubmed]
  28. Prolactin and testicular Leydig cell function: characterization of prolactin receptors in the murine MA-10 testicular Leydig cell line. Barkey, R.J., Weiss-Messer, E., Hacham, H., Herscovich, S., Ber, R., Amit, T. Proc. Soc. Exp. Biol. Med. (1994) [Pubmed]
  29. Effects of passive immunization against parathyroid hormone (PTH)-like peptide and PTH in hypercalcemic tumor-bearing rats and normocalcemic controls. Henderson, J., Bernier, S., D'Amour, P., Goltzman, D. Endocrinology (1990) [Pubmed]
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