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Chemical Compound Review:

PubChem8201 2-amino-5-nitro-phenol

Synonyms: AC1NLLZT, CCRIS 754, Rodol YBA, CHEMBL164989, SureCN123756, ...

Anderson, M.M. et al., Chen, F. et al.

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High impact information on CCRIS 754

Microsomes did not catalyze the isomerization of N-hydroxy-4-nitroaniline to 2-hydroxy-4-nitroaniline [1].
The principal rat liver microsomal metabolite of 4-nitroaniline was isolated by high pressure liquid chromatography and was characterized as 2-amino-5-nitrophenol (2-hydroxy-4-nitroaniline) by comparison of its mass, nuclear magnetic resonance, and ultraviolet spectra and HPLC retention time to the synthetic compound [1].
Two hair dye components, carcinogenic 4-nitro-2-aminophenol and 5-nitro-2-aminophenol, induced Cu(II)-dependent DNA cleavage frequently at thymine and guanine residues in DNA fragments obtained from the c-Ha-ras-1 protooncogene [2].

References

Metabolism of 4-nitroaniline by rat liver microsomes. Anderson, M.M., Mays, J.B., Mitchum, R.K., Hinson, J.A. Drug Metab. Dispos. (1984) [Pubmed]
Metal-mediated oxidative DNA damage induced by nitro-2-aminophenols. Chen, F., Oikawa, S., Hiraku, Y., Murata, M., Yamashita, N., Kawanishi, S. Cancer Lett. (1998) [Pubmed]

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