Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Khinalizarin 1,2,5,8- tetrahydroxyanthracene-9,10- dione

Synonyms: quinalizarin, Quinalizarine, CHEMBL29898, SureCN138122, NSC-4896, ...

Seegers, J.C. et al., Shama, S.A., Snyder, K.L. et al.

Shama,

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High impact information on quinalizarin

The proposed methods are based on the formation of ion-pair complexes between the examined drugs with alizarine (Aliz), alizarine red S (ARS), alizarine yellow G (AYG) or quinalizarine (Qaliz), which can be measured at the optimum lambda(max) [1].
Quinalizarin treatment in the presence of 2-MeOE2 had no effect on the large number of abnormal metaphases [2].
The reduction in the number of HeLa cells with abnormal metaphase configurations after exposure to 2-OHE2 plus quinalizarin (an inhibitor of catechol-O-methyltransferase) indicated that the production of 2-MeOE2 is necessary for the formation of abnormal spindles in metaphase [2].

Analytical, diagnostic and therapeutic context of quinalizarin

The system exhibits a linear dynamic range of 3 orders of magnitude (30 nM to 30 microM quinalizarin at 470 nm) for static measurements and 2 orders of magnitude (0.5 microM to 50 microM) for HPLC measurements [3].

References

Spectrophotometric determination of phenylephrine HCl and orphenadrine citrate in pure and in dosage forms. Shama, S.A. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells. Seegers, J.C., Aveling, M.L., Van Aswegen, C.H., Cross, M., Koch, F., Joubert, W.S. J. Steroid Biochem. (1989) [Pubmed]
Cavity ring-down spectroscopy as a detector for liquid chromatography. Snyder, K.L., Zare, R.N. Anal. Chem. (2003) [Pubmed]

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