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Chemical Compound Review:

AC1L9X76 (2S,3R,4S,5S)-2- (hydroxymethyl)-5-[(5S)-5...

Synonyms:

Shimazaki, M. et al., Hidaka, T. et al.

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High impact information on AIDS165589

These indicate that the deamination of formycin A and ara-A is blocked by isocoformycin in vivo [1].
Studies on inhibition of adenosine deaminase by isocoformycin in vitro and in vivo [2].

Anatomical context of AIDS165589

Following intraperitoneal injection of isocoformycin in mice, the adenosine deaminase activity of homogenates of several organs was determined and the following ED50 values (50% inhibition doses) were observed: 29 mg/kg for thymus, 13 mg/kg for spleen, 80 mg/kg for liver and 20 mg/kg for kidney [2].

Analytical, diagnostic and therapeutic context of AIDS165589

Single intraperitoneal and intravenous injections of isocoformycin at 1,200 mg/kg did not cause the death of mice [1].

References

Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-beta-D-arabinofuranosyladenine. Hidaka, T., Katayama, K., Yamashita, K., Yamashita, T., Watanabe, K., Shimazaki, M., Ohno, M., Takeuchi, T., Umezawa, H. J. Antibiot. (1980) [Pubmed]
Studies on inhibition of adenosine deaminase by isocoformycin in vitro and in vivo. Shimazaki, M., Kumada, Y., Takeuchi, T., Umezawa, H., Watanabe, K. J. Antibiot. (1979) [Pubmed]

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