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Gene Review

Ada  -  adenosine deaminase

Mus musculus

Synonyms: Adenosine aminohydrolase, Adenosine deaminase
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Disease relevance of Ada


Psychiatry related information on Ada


High impact information on Ada


Chemical compound and disease context of Ada


Biological context of Ada


Anatomical context of Ada


Associations of Ada with chemical compounds


Regulatory relationships of Ada


Other interactions of Ada

  • From the current data Ada can be taken as the proximal, and Ra as the distal gene marker of the imprinting region on the linkage map [21].
  • Chromosomal mapping of enzyme loci in the domestic cat: GSR to C2, ADA and ITPA to A3, and LDHA-ACP2 to D1 [22].
  • Deletion of ADA improved outcome from 25 min ischaemia, reducing ventricular diastolic pressure (by 45%; 21+/-4 vs. 38+/-3mm Hg) and lactate dehydrogenase (LDH) efflux (by 40%; 0.12+/-0.01 vs. 0.21+/-0.02 U/g/min ischaemia), and enhancing pressure development (by 35%; 89+/-6 vs. 66+/-5mm Hg) [2].
  • Fibroblasts were engineered to release adenosine by inactivating the adenosine-metabolizing enzymes adenosine kinase and adenosine deaminase [23].
  • In cotransfection assays, increased mGPBP expression transactivated the murine Ada gene's promoter [24].

Analytical, diagnostic and therapeutic context of Ada


  1. Factors affecting the transduction of pluripotent hematopoietic stem cells: long-term expression of a human adenosine deaminase gene in mice. Einerhand, M.P., Bakx, T.A., Kukler, A., Valerio, D. Blood (1993) [Pubmed]
  2. Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Willems, L., Reichelt, M.E., Molina, J.G., Sun, C.X., Chunn, J.L., Ashton, K.J., Schnermann, J., Blackburn, M.R., Headrick, J.P. Cardiovasc. Res. (2006) [Pubmed]
  3. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. Blackburn, M.R., Volmer, J.B., Thrasher, J.L., Zhong, H., Crosby, J.R., Lee, J.J., Kellems, R.E. J. Exp. Med. (2000) [Pubmed]
  4. Behavioral characteristics of centrally administered adenosine analogs. Phillis, J.W., Barraco, R.A., DeLong, R.E., Washington, D.O. Pharmacol. Biochem. Behav. (1986) [Pubmed]
  5. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Higuchi, M., Single, F.N., Köhler, M., Sommer, B., Sprengel, R., Seeburg, P.H. Cell (1993) [Pubmed]
  6. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Wang, Q., Khillan, J., Gadue, P., Nishikura, K. Science (2000) [Pubmed]
  7. Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. Wilson, D.K., Rudolph, F.B., Quiocho, F.A. Science (1991) [Pubmed]
  8. Synergistic effect of 3'-deoxyadenosine N1-oxide and adenosine deaminase inhibitors on growth of Ehrlich ascites tumor cells in vivo. Svendsen, K.R., Overgaard-Hansen, K., Frederiksen, S. Cancer Chemother. Pharmacol. (1988) [Pubmed]
  9. Purine excretion by mouse peritoneal macrophages lacking adenosine deaminase activity. Chan, T.S. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  10. Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin. Cass, C.E., Au-Yeung, T.H. Cancer Res. (1976) [Pubmed]
  11. Regulation of murine Ada gene expression in the placenta by transcription factor RUNX1. Schaubach, B.M., Wen, H.Y., Kellems, R.E. Placenta (2006) [Pubmed]
  12. Adenosine deaminase, Ada, is in mouse chromosome 2H3, and is not allelic with wasted, wst. Abbott, C.M., Evans, E.P., Burtenshaw, M., Ball, S.T., Skidmore, C.J., Jones, J., Peters, J. Biochem. Genet. (1991) [Pubmed]
  13. Purine nucleoside metabolizing enzyme activities in mouse thymocytes at different stages of differentiation and maturation. Kizaki, H., Habu, S., Ohsaka, F., Sakurada, T. Cell. Immunol. (1983) [Pubmed]
  14. Regulation of forestomach-specific expression of the murine adenosine deaminase gene. Xu, P.A., Winston, J.H., Datta, S.K., Kellems, R.E. J. Biol. Chem. (1999) [Pubmed]
  15. The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. Cronstein, B.N., Naime, D., Ostad, E. J. Clin. Invest. (1993) [Pubmed]
  16. Transcription factor gene AP-2 gamma essential for early murine development. Werling, U., Schorle, H. Mol. Cell. Biol. (2002) [Pubmed]
  17. Adenosine acts as an endogenous modulator of IL-2-dependent proliferation of cytotoxic T lymphocytes. Antonysamy, M.A., Moticka, E.J., Ramkumar, V. J. Immunol. (1995) [Pubmed]
  18. Improved synthesis of 2'-deoxyformycin A and studies of its in vitro activity against mouse lymphoma of T-cell origin. Rosowsky, A., Solan, V.C., Gudas, L.J. J. Med. Chem. (1985) [Pubmed]
  19. Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation. Van De Wiele, C.J., Vaughn, J.G., Blackburn, M.R., Ledent, C.A., Jacobson, M., Jiang, H., Thompson, L.F. J. Clin. Invest. (2002) [Pubmed]
  20. Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development. Shi, D., Kellems, R.E. J. Biol. Chem. (1998) [Pubmed]
  21. Mapping studies of the distal imprinting region of mouse chromosome 2. Peters, J., Beechey, C.V., Ball, S.T., Evans, E.P. Genet. Res. (1994) [Pubmed]
  22. Chromosomal mapping of enzyme loci in the domestic cat: GSR to C2, ADA and ITPA to A3, and LDHA-ACP2 to D1. Berman, E.J., Nash, W.G., Seuánez, H.N., O'Brien, S.J. Cytogenet. Cell Genet. (1986) [Pubmed]
  23. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Huber, A., Padrun, V., Déglon, N., Aebischer, P., Möhler, H., Boison, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  24. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Hsu, L.C., Liu, S., Abedinpour, F., Beech, R.D., Lahti, J.M., Kidd, V.J., Greenspan, J.A., Yeung, C.Y. Mol. Cell. Biol. (2003) [Pubmed]
  25. Molecular cloning of the murine adenosine deaminase gene from a genetically enriched source: identification and characterization of the promoter region. Ingolia, D.E., Al-Ubaidi, M.R., Yeung, C.Y., Bigo, H.A., Wright, D., Kellems, R.E. Mol. Cell. Biol. (1986) [Pubmed]
  26. Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture. Van De Wiele, C.J., Joachims, M.L., Fesler, A.M., Vaughn, J.G., Blackburn, M.R., McGee, S.T., Thompson, L.F. J. Immunol. (2006) [Pubmed]
  27. Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. Blackburn, M.R., Datta, S.K., Kellems, R.E. J. Biol. Chem. (1998) [Pubmed]
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