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Chemical Compound Review:

AC1NOQVT 2-bromoethanesulfonate

Synonyms: STL283966, ZINC04261812, FT-0674617, ST45026418

This record was replaced with 33662.

Boyd, J.M. et al., Scheel, E. et al., Beller, H.R., Freedman, D.L. et al.

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Disease relevance of NSC447

In the present work the CoM analog 2-bromoethanesulfonate (BES) was shown to be a specific inhibitor of propylene-dependent growth of and epoxypropane metabolism by Xanthobacter autotrophicus strain Py2 [1].

High impact information on NSC447

Studies with the inhibitor 2-bromoethanesulfonate suggested that methanogens played a key role in the observed biotransformations of PCE and TCE [2].
2-Bromoethanesulfonate, an inhibitor of methanogenesis, had no effect on the membrane potential but, like (cHxN)2C and protonophores, decreased the intracellular ATP concentration [3].
Methanogens were unlikely to be responsible for RDX metabolism, as the presence of 2-bromoethanesulfonate, an inhibitor of methanogenesis, did not appear to affect RDX metabolism [4].

References

Characterization of 2-bromoethanesulfonate as a selective inhibitor of the coenzyme m-dependent pathway and enzymes of bacterial aliphatic epoxide metabolism. Boyd, J.M., Ellsworth, A., Ensign, S.A. J. Bacteriol. (2006) [Pubmed]
Biological reductive dechlorination of tetrachloroethylene and trichloroethylene to ethylene under methanogenic conditions. Freedman, D.L., Gossett, J.M. Appl. Environ. Microbiol. (1989) [Pubmed]
Chemiosmotic energy conversion and the membrane ATPase of Methanolobus tindarius. Scheel, E., Schäfer, G. Eur. J. Biochem. (1990) [Pubmed]
Anaerobic biotransformation of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) by aquifer bacteria using hydrogen as the sole electron donor. Beller, H.R. Water Res. (2002) [Pubmed]

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