Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Nohdabz N-[4-[4-(ethanoyl-hydroxy...

Synonyms: CCRIS 1411, AG-G-80797, AC1L1AXD, LS-13069, CTK5D4723, ...

Morton, K.C. et al., Ciotti, M. et al., Morton, K.C. et al.

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Disease relevance of Nohdabz

A preliminary dose-response test showed that NOHDABZ was the most toxic compound; it caused chemical peritonitis and death in each of 4 animals given 70 mumol/kg body weight/injected [1].

High impact information on Nohdabz

Metabolic activation of N-hydroxy-N,N'-diacetylbenzidine by hepatic sulfotransferase [2].
UGT1A1 demonstrated more extensive metabolism of the hydroxamic acid, N-hydroxy-N,N'-diacetylbenzidine, and the ring oxidation product, 3-OH-N,N'-diacetylbenzidine, than it did for the other six amines [3].
UGT1A9 exhibited the highest relative rates of metabolism with preference for the two hydroxamic acids, N-hydroxy-N-acetylbenzidine and N-hydroxy-N,N'-diacetylbenzidine [3].
The metabolites were approximately equipotent with BZ in mammary and Zymbal's gland, but the amount of NOHDABZ actually reaching these organs may have been diminished by local reactions of NOHDABZ within the peritoneum [1].

References

Carcinogenicity of benzidine, N,N'-diacetylbenzidine, and N-hydroxy-N,N'-diacetylbenzidine for female CD rats. Morton, K.C., Wang, C.Y., Garner, C.D., Shirai, T. Carcinogenesis (1981) [Pubmed]
Metabolic activation of N-hydroxy-N,N'-diacetylbenzidine by hepatic sulfotransferase. Morton, K.C., Beland, F.A., Evans, F.E., Fullerton, N.F., Kadlubar, F.F. Cancer Res. (1980) [Pubmed]
Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides. Ciotti, M., Lakshmi, V.M., Basu, N., Davis, B.B., Owens, I.S., Zenser, T.V. Carcinogenesis (1999) [Pubmed]

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